Naslov
Antibacterial, cytotoxic, and antioxidative effects of benzoxanthene lignans

Autori
Huđek Turković, Ana ; Tumir, Lidija Marija ; Zonjić, Iva ; Durgo, Ksenija ; Radić Brkanac, Sandra ; Žuna, Kristina ; Crnolatac, Ivo ; Tringali, Corrado ; Radić Stojković, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 6th Croatian Congress of Toxicology with International Participation CROTOX 2021, Arhiv za higijenu rada i toksikologiju 2021 ; 72 (Suppl. 1) / Lyons, Daniel M. ; Brčić Karačonji, I ; Kopjar, N. ; Herman, M. - Zagreb : Institute for Medical Research and Occupational Health, Zagreb, Croatia, 2021, 45-45

Skup
6th Croatian congress of toxicology with international participation (CROTOX 2021)

Mjesto i datum
Rabac, Hrvatska, 03.10.2021. - 06.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
benzoxanthene lignans ; antibacterial effect ; human cell line ; cytotoxicity ; antioxidative effect

Sažetak
Benzoxanthene lignans are natural compounds that have been isolated from various plants, but not very much is known about their biological activity. This study investigated the antibacterial, cytotoxic and antioxidant effects of eight different benzoxanthene lignans synthesized by oxidative coupling of caffeic acid and methyl caffeate. Results showed that all benzoxanthene lignans exhibited significant antibacterial effects against Gram positive bacteria at concentrations of 0.5 and 0.05 mmol/L. Seven of them showed significant cytotoxic effects on human liver cancer cells at a concentration of 0.05 mmol/L, with phenyl and hydroxyl groups in the structure being responsible for their effective tumor cell growth inhibition. All benzoxanthene lignans showed significant antioxidative effects at a concentration of 0.05 mmol/L. C-6, C-9 and C-10 hydroxyl groups were proven to be important for such antioxidative activity.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Biotehnologija, Interdisciplinarne biotehničke znanosti

POVEZANOST RADA