Naslov
Utjecaj galne kiseline na taloženje kalcijeva oksalata
(Influence of gallic acid on calcium oxalate precipitation)

Autori
Goman, Sara

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, preddiplomski

Fakultet
Odjel za kemiju

Mjesto
Osijek

Datum
29.09

Godina
2021

Stranica
16

Mentor
Stanković, Anamarija ; Jokić, Stela

Neposredni voditelj
Šafranko, Silavija

Ključne riječi
calcium oxalate monohydrate ; calcium oxalate dihydrate ; response surface methodology ; pathological biomineralization ; gallic acid

Sažetak
The search for an efficient drug or inhibitor in the formation process of kidney stones has been a promising research topic towards reducing the risks of the formation of disease. However, several challenges have been faced in investigating the most common constituents of kidney stones, calcium oxalate and its hydrate forms (COM, COD and COT). This study focuses on the preparation and structural characterization (TG, XRD, FTIR, SEM) of calcium oxalate hydrates in the presence of gallic acid (GA) and by varying operating parameters such as temperature (25 ◦C, 36.5 ◦C and 48 ◦C), pH (5.6, 6.5 and 7.5) and amount of added GA (ranging from 100 mg to 1000 mg). Response surface methodology was applied in order to evaluate the effects of operating parameters in the formation of COM and COD, and for the process optimization towards maximizing their content in samples. The results indicated that GA inhibited the formation of COM (0–100%) and promoted the formation of COD (0 ≤ 99%), while a medium pH and the amount of added GA showed a significant effect in the process of COD formation. In order to investigate the interactions established in the formation process and the possible adsorption between GA and the formed crystals, electrochemical measurements were performed. Zavrsni rad je izradjen u sklopu znanstvenog rada naslova: "Calcium Oxalate and Gallic Acid: Structural Characterization and Process Optimization toward Obtaining High Contents of Calcium Oxalate Monohydrate and Dihydrate", autora Silvije Šafranko, Sare Goman, Dominika Gomana, Stele Jokić, Ide Delač Marion, Nives Matijaković Mlinarić, Atiđe Selmani, Martine Medvidović- Kosanović i Anamarije Stanković, objavljenog u časopisu Crystals.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Interdisciplinarne biotehničke znanosti

POVEZANOST RADA