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Pregled bibliografske jedinice broj: 1147067

Lifelong changes after perinatal moderate hypoxia: increased number of interneurons and perineuronal nets in the cingulate cortex of the adult rat

Trnski, Sara; Nikolić, Barbara; Ilić, Katarina; Drlje, Matea; Bobić-Rasonja, Mihaela; Darmopil, Sanja; Petanjek, Zdravko; Hranilović, Dubravka; Jovanov-Milošević, Nataša
Lifelong changes after perinatal moderate hypoxia: increased number of interneurons and perineuronal nets in the cingulate cortex of the adult rat // 8th Croatian neuroscience congress : book of abstracts
Zagreb, 2021. str. 103-103 (poster, domaća recenzija, sažetak, stručni)

CROSBI ID: 1147067 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Lifelong changes after perinatal moderate hypoxia: increased number of interneurons and perineuronal nets in the cingulate cortex of the adult rat

Autori
Trnski, Sara ; Nikolić, Barbara ; Ilić, Katarina ; Drlje, Matea ; Bobić-Rasonja, Mihaela ; Darmopil, Sanja ; Petanjek, Zdravko ; Hranilović, Dubravka ; Jovanov-Milošević, Nataša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
8th Croatian neuroscience congress : book of abstracts / - Zagreb, 2021, 103-103

Skup
8th Croatian neuroscience congress

Mjesto i datum
Online, 24.09.2021. - 25.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
learning pattern ; connectivity development ; oxidative stress ; hyperactivity behavior

Sažetak
We designed a non-invasive model in newborn rats to determine the hallmarks of possible permanent structural and behavioral changes in the brain after moderate perinatal hypoxia. The 82 Wistar Han (RccHan: WIST) rats were randomly subjected to hypoxia (pO2 73mmHg/2h) or normoxia at the first postnatal day. The increase of hypoxia-inducible factor-1α and decreased cytochrome-C-oxygenase expression in treated animals' brains, detected by Western blot, confirmed an acute moderate lesion. The results of the open-field, hole-board, social- choice, and T-maze tests, applied at the 30 - 45th and 70-85th postnatal days, displayed significant hyperactivity and a slower pace of learning in rats subjected to perinatal hypoxia. At 3.5 months of age, the histochemical examination revealed a significantly increased number of specific extracellular matrix-perineuronal nets and parvalbumin-expressing interneurons in the medial and retrosplenial cingulate cortex of these animals. Conclusively, moderate perinatal hypoxia in the rat causes lifelong cellular and connectivity organization changes in the cingulate cortex and related behavioral and cognitive alterations. This non-invasive hypoxia in the rat successfully and complementary models the frequently unrecognized moderate perinatal brain injury in fetuses in humans and may enhance future research of new diagnostic and therapeutic strategies for perinatal brain injuries.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
--IP-2019-04-3182 - Moždani izvanstanični matriks u razvitku i perinatalnoj hipoksiji (BRAINECM) (Jovanov Milošević, Nataša) ( CroRIS)
--KK.01.1.1.01.0007 - Znanstveni centar izvrnosti - Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi (ZCI - NEURO) (Judaš, Miloš) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Mihaela Bobić (autor)

Avatar Url Barbara Nikolić (autor)

Avatar Url Zdravko Petanjek (autor)

Avatar Url Nataša Jovanov Milošević (autor)

Avatar Url Sanja Darmopil (autor)

Avatar Url Katarina Ilić (autor)

Avatar Url Matea Drlje (autor)

Avatar Url Sara Trnski (autor)

Avatar Url Dubravka Hranilović (autor)

Poveznice na cjeloviti tekst rada:

www.hdn.hr

Citiraj ovu publikaciju:

Trnski, Sara; Nikolić, Barbara; Ilić, Katarina; Drlje, Matea; Bobić-Rasonja, Mihaela; Darmopil, Sanja; Petanjek, Zdravko; Hranilović, Dubravka; Jovanov-Milošević, Nataša
Lifelong changes after perinatal moderate hypoxia: increased number of interneurons and perineuronal nets in the cingulate cortex of the adult rat // 8th Croatian neuroscience congress : book of abstracts
Zagreb, 2021. str. 103-103 (poster, domaća recenzija, sažetak, stručni)
Trnski, S., Nikolić, B., Ilić, K., Drlje, M., Bobić-Rasonja, M., Darmopil, S., Petanjek, Z., Hranilović, D. & Jovanov-Milošević, N. (2021) Lifelong changes after perinatal moderate hypoxia: increased number of interneurons and perineuronal nets in the cingulate cortex of the adult rat. U: 8th Croatian neuroscience congress : book of abstracts.
@article{article, author = {Trnski, Sara and Nikoli\'{c}, Barbara and Ili\'{c}, Katarina and Drlje, Matea and Bobi\'{c}-Rasonja, Mihaela and Darmopil, Sanja and Petanjek, Zdravko and Hranilovi\'{c}, Dubravka and Jovanov-Milo\v{s}evi\'{c}, Nata\v{s}a}, year = {2021}, pages = {103-103}, keywords = {learning pattern, connectivity development, oxidative stress, hyperactivity behavior}, title = {Lifelong changes after perinatal moderate hypoxia: increased number of interneurons and perineuronal nets in the cingulate cortex of the adult rat}, keyword = {learning pattern, connectivity development, oxidative stress, hyperactivity behavior}, publisherplace = {online} }
@article{article, author = {Trnski, Sara and Nikoli\'{c}, Barbara and Ili\'{c}, Katarina and Drlje, Matea and Bobi\'{c}-Rasonja, Mihaela and Darmopil, Sanja and Petanjek, Zdravko and Hranilovi\'{c}, Dubravka and Jovanov-Milo\v{s}evi\'{c}, Nata\v{s}a}, year = {2021}, pages = {103-103}, keywords = {learning pattern, connectivity development, oxidative stress, hyperactivity behavior}, title = {Lifelong changes after perinatal moderate hypoxia: increased number of interneurons and perineuronal nets in the cingulate cortex of the adult rat}, keyword = {learning pattern, connectivity development, oxidative stress, hyperactivity behavior}, publisherplace = {online} }

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