Naslov
Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology

Autori
Werner, Anja ; Schäfer, Simon ; Zaytseva, Olga ; Albert, Heike ; Lux, Anja ; Krištić, Jasminka ; Pezer, Marija ; Lauc, Gordan ; Winkler, Thomas ; Nimmerjahn, Falk

Izvornik
IScience (2589-0042) 24 (2021), 9; 103076, 27

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
systemic lupus erythematosus

Sažetak
Systemic lupus erythematosus (SLE) is characterized by a loss of self-tolerance, systemic inflammation, and multi-organ damage. While a variety of therapeutic interventions are available, it has become clear that an early diagnosis and treatment may be key to achieve long lasting therapeutic responses and to limit irreversible organ damage. Loss of humoral tolerance including the appearance of self- reactive antibodies can be detected years before the actual onset of the clinical autoimmune disease, representing a potential early point of intervention. Not much is known, however, about how and to what extent this pre-phase of disease impacts the onset and development of subsequent autoimmunity. By targeting the B cell compartment in the pre-disease phase of a spontaneous mouse model of SLE we now show, that resetting the humoral immune system during the clinically unapparent phase of the disease globally alters immune homeostasis delaying the downstream development of systemic autoimmunity.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Veterinarska medicina

POVEZANOST RADA