Naslov
Synthesis, characterization and stability studies of 10, 11-dihydrocinchonidine carbamates

Autori
Ramić, Alma ; Primožič, Ines ; Hrenar, Tomica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Adriatic NMR Conference 2021: Book of abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena - Zagreb : Hrvatsko kemijsko društvo, 2021, 65-65

Skup
The Adriatic NMR Conference 2021

Mjesto i datum
Primošten, Hrvatska, 13.09.2021. - 15.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
10, 11-dihydrocinchonidine ; carbamates ; NMR spectroscopy

Sažetak
Cinchonidine, together with cinchonine, quinine and quinidine, is natural alkaloid isolated on industrial scale from the bark of the Cinchona tree.[1] Cinchona alkaloids and their derivatives have application as chiral resolving agents in NMR spectroscopy and as chiral stationary phases for chromatographic separation of different analytes. [2] 10, 11-dihydrocinchonidine was prepared by transfer hydrogenation of cinchonidine over a palladium on carbon catalyst using formic acid/ammonium formate as hydrogen donor.[3] A series of monosubstituted aromatic (phenyl group) and disubstituted aliphatic or aromatic (methyl, ethyl and phenyl groups) 10, 11- dihydrocinchonidine carbamates have been prepared by reaction of 10, 11-dihydrocinchonidine with appropriately substituted isocyanates or carbamoyl chlorides. The structures of all prepared carbamates were confirmed by 1D, 2D 1H and 13C NMR spectroscopy techniques. Evaluation of stability for prepared carbamates in solution was assessed by 1H NMR spectroscopy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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