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Pregled bibliografske jedinice broj: 1145503

Environmental Factors Affecting Thyroid- Stimulating Hormone and Thyroid Hormone Levels


Babić Leko, Mirjana; Gunjača, Ivana; Pleić, Nikolina; Zemunik, Tatijana
Environmental Factors Affecting Thyroid- Stimulating Hormone and Thyroid Hormone Levels // International Journal of Molecular Sciences, 22 (2021), 12; 6521, 62 doi:10.3390/ijms22126521 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Environmental Factors Affecting Thyroid- Stimulating Hormone and Thyroid Hormone Levels
(Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels)

Autori
Babić Leko, Mirjana ; Gunjača, Ivana ; Pleić, Nikolina ; Zemunik, Tatijana

Izvornik
International Journal of Molecular Sciences (1422-0067) 22 (2021), 12; 6521, 62

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
thyroid hormones ; TSH ; environmental factors ; lifestyle factors ; pollutants ; diet ; chemicals

Sažetak
Thyroid hormones are necessary for the normal functioning of physiological systems. Therefore, knowledge of any factor (whether genetic, environmental or intrinsic) that alters the levels of thyroid-stimulating hormone (TSH) and thyroid hormones is crucial. Genetic factors contribute up to 65% of interindividual variations in TSH and thyroid hormone levels, but many environmental factors can also affect thyroid function. This review discusses studies that have analyzed the impact of environmental factors on TSH and thyroid hormone levels in healthy adults. We included lifestyle factors (smoking, alcohol consumption, diet and exercise) and pollutants (chemicals and heavy metals). Many inconsistencies in the results have been observed between studies, making it difficult to draw a general conclusion about how a particular environmental factor influences TSH and thyroid hormone levels. However, lifestyle factors that showed the clearest association with TSH and thyroid hormones were smoking, body mass index (BMI) and iodine (micronutrient taken from the diet). Smoking mainly led to a decrease in TSH levels and an increase in triiodothyronine (T3) and thyroxine (T4) levels, while BMI levels were positively correlated with TSH and free T3 levels. Excess iodine led to an increase in TSH levels and a decrease in thyroid hormone levels. Among the pollutants analyzed, most studies observed a decrease in thyroid hormone levels after exposure to perchlorate. Future studies should continue to analyze the impact of environmental factors on thyroid function as they could contribute to understanding the complex background of gene–environment interactions underlying the pathology of thyroid diseases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Nutricionizam



POVEZANOST RADA


Projekti:
HRZZ-IP-2019-04-2593 - Reguliranje funkcije štitne i doštitne žlijezde i homeostaze kalcija u krvi (THPTHCAREGULATION) (Zemunik, Tatijana, HRZZ ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Babić Leko, Mirjana; Gunjača, Ivana; Pleić, Nikolina; Zemunik, Tatijana
Environmental Factors Affecting Thyroid- Stimulating Hormone and Thyroid Hormone Levels // International Journal of Molecular Sciences, 22 (2021), 12; 6521, 62 doi:10.3390/ijms22126521 (međunarodna recenzija, pregledni rad, znanstveni)
Babić Leko, M., Gunjača, I., Pleić, N. & Zemunik, T. (2021) Environmental Factors Affecting Thyroid- Stimulating Hormone and Thyroid Hormone Levels. International Journal of Molecular Sciences, 22 (12), 6521, 62 doi:10.3390/ijms22126521.
@article{article, author = {Babi\'{c} Leko, Mirjana and Gunja\v{c}a, Ivana and Plei\'{c}, Nikolina and Zemunik, Tatijana}, year = {2021}, pages = {62}, DOI = {10.3390/ijms22126521}, chapter = {6521}, keywords = {thyroid hormones, TSH, environmental factors, lifestyle factors, pollutants, diet, chemicals}, journal = {International Journal of Molecular Sciences}, doi = {10.3390/ijms22126521}, volume = {22}, number = {12}, issn = {1422-0067}, title = {Environmental Factors Affecting Thyroid- Stimulating Hormone and Thyroid Hormone Levels}, keyword = {thyroid hormones, TSH, environmental factors, lifestyle factors, pollutants, diet, chemicals}, chapternumber = {6521} }
@article{article, author = {Babi\'{c} Leko, Mirjana and Gunja\v{c}a, Ivana and Plei\'{c}, Nikolina and Zemunik, Tatijana}, year = {2021}, pages = {62}, DOI = {10.3390/ijms22126521}, chapter = {6521}, keywords = {thyroid hormones, TSH, environmental factors, lifestyle factors, pollutants, diet, chemicals}, journal = {International Journal of Molecular Sciences}, doi = {10.3390/ijms22126521}, volume = {22}, number = {12}, issn = {1422-0067}, title = {Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels}, keyword = {thyroid hormones, TSH, environmental factors, lifestyle factors, pollutants, diet, chemicals}, chapternumber = {6521} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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