Pregled bibliografske jedinice broj: 1144256
A computational study of bio-chemo-mechanical role of intraluminal thrombus in the aneurysm progression using finite elements
A computational study of bio-chemo-mechanical role of intraluminal thrombus in the aneurysm progression using finite elements // COMPLAS 2021
Barcelona, Španjolska, 2021. str. 1077-1077 (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1144256 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
A computational study of bio-chemo-mechanical
role of intraluminal thrombus in the aneurysm
progression using finite elements
Autori
Virag, Lana ; Horvat, Nino ; Karšaj, Igor
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
COMPLAS 2021
/ - , 2021, 1077-1077
Skup
XVI International Conference on Computational Plasticity. Fundamentals and Applications
Mjesto i datum
Barcelona, Španjolska, 07.09.2021. - 09.09.2021
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
growth and remodelling, intraluminal trombus, finite elements
Sažetak
Intraluminal thrombus (ILT) is usually clinically perceived negatively. It hinders the endovascular treatment and is believed to hasten the rupture. Yet, various clinical, histological, experimental, and computational studies came to conflicting results, some confirming the presumption that ILT impacts abdominal aortic aneurysm (AAA) outcome negatively, and others opposing it. However, all studies agree that ILT plays an important role in disease development and outcome. The aim of this study is to investigate comprehensively the bio-chemo-mechanical role ILT plays during AAA progression. To our finite element implementation of the arterial wall growth and remodelling presented in [1], a bio- chemo-mechanical model of ILT is added. Thrombus model is based on the work from [2] that showed promising results, as it was able to replicate clinical expectations for different rupture risk and stabilization factors [3]. However, it was applied to a simplified cylindrical geometry that does not represent aneurysms well and was, consequently, unable to track changes in the shoulder region. Using finite element method on more realistic AAA geometry, we show that ILT mechanically shields AAA in an unexpected way. It is likely that thrombus acts against the rapid axial expansion of the lesion and, consequently, the rupture. Furthermore, we show that thin thrombus is perilous: mechanically, it is shielding the wall ; however, that also means that it reduces the production of wall constituents. Biochemically, it is well known that the luminal layer is proteolytically the most active [4], degrading and weakening the wall further. Finally, we emphasize the need to understand the direction of protease diffusion from ILT to the aortic wall (radial vs. perpendicular to the wall – i.e., through the shortest distance), as well as the protease diffusion in the shoulder region, as it also plays mayor role in AAA outcome.
Izvorni jezik
Engleski
Znanstvena područja
Strojarstvo, Interdisciplinarne tehničke znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2020-02-4016 - Numerička procjena rizika od rupture nekomplicirane disekcije aorte tipa B (LessPatients) (Tuković, Željko, HRZZ - 2020-02) ( CroRIS)
Ustanove:
Fakultet strojarstva i brodogradnje, Zagreb