Pregled bibliografske jedinice broj: 1143941
Saliva and healing of oral mucosa
Saliva and healing of oral mucosa // 9th Croatian Congress of Pharmacology with International Participation Book of Abstracts
Zagreb, 2019. str. 13-13 (predavanje, međunarodna recenzija, sažetak, stručni)
CROSBI ID: 1143941 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Saliva and healing of oral mucosa
Autori
Vuletić, Lea
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni
Izvornik
9th Croatian Congress of Pharmacology with International Participation Book of Abstracts
/ - Zagreb, 2019, 13-13
Skup
9. hrvatski kongres farmakologije = 9th Croatian Congress of Pharmacology
Mjesto i datum
Zagreb, Hrvatska, 25.09.2019. - 28.09.2019
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
healing process ; oral mucosa ; saliva
Sažetak
Physiological roles of saliva are inseparable from the main physiological roles of oral cavity – eating and speaking – which saliva supports by moisturizing and lubricating oropharyngeal tissues. Saliva is also indispensable for maintaining health of both hard (mineralized) dental tissues as well as oral mucosa. However, when lesions affecting oral mucosa do occur, can saliva promote healing? It has been suggested that several active substances present in saliva could be beneficially involved in the healing process. These include growth factors like epidermal growth factor and vascular endothelial growth factor, and, particularly, histatins, a family of cationic histidine-rich salivary peptides. Proposed mechanisms of action include influence on the infiltration of inflammatory cells, accelerating migration and proliferation of oral epithelial cells and fibroblasts, inciting remodeling of the extracellular matrix, and promoting proliferation of endothelial cells and forming of new blood vessels. Revealing a role of a particular salivary substance in the healing of mucosal lesions allows for the possibility of designing and conducting studies exploring their therapeutic potential. Effective and safe novel therapeutics promoting regeneration of oral mucosa and relieving pain would be particularly beneficial in conditions which substantialy impair patients' quality of life and are often difficult to prevent or to treat such as mucosal changes (mucositis and ulcerations) related to hyposalivation, and oral mucositis occuring as a side effect of chemotherapy and head and neck radiotherapy.
Izvorni jezik
Engleski
Znanstvena područja
Dentalna medicina
