Naslov
Evaluation of Changes in Metabolites of Saliva in Canine Obesity Using a Targeted Metabolomic Approach

Autori
Muñoz-Prieto, Alberto ; Rubić, Ivana ; Horvatić, Anita ; Rafaj, Renata Barić ; Cerón, José Joaquín ; Tvarijonaviciute, Asta ; Mrljak, Vladimir

Izvornik
Animals (2076-2615) 11 (2021), 9; 2501, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
obesity ; dogs ; saliva ; targeted metabolomics ; biomarkers

Sažetak
Obesity is a common problem in pet dogs, affecting half of the general population in some countries. Excess body weight causes several disorders and has a negative impact on dogs’ quality of life. The use of metabolomics allows the identification of metabolite traces from the metabolic pathways involved in pathological processes. This study aimed to evaluate salivary metabolite variations in dogs with obesity. The salivary samples of 19 dogs were analyzed using a targeted metabolomic approach, through which 234 metabolites were quantified. Of these, multivariate analysis identified 27 different metabolites altered in dogs with obesity compared with control dogs. These metabolites were mainly classified as amino acids, glycerides, sphingolipids, glycerophospholipids, and acylcarnitines. Some of the changes in these metabolites reflect the insulin resistance status related to obesity in dogs. Overall, it can be concluded that the salivary metabolome of obese dogs reflects the metabolic changes occurring in obesity and could be a source of potential biomarkers for this complex condition.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kliničke medicinske znanosti, Veterinarska medicina

POVEZANOST RADA