Pregled bibliografske jedinice broj: 1142998
New aroyl hydrazones combined with specific peptide analogues: looking for possible enhanced cytotoxic effects
New aroyl hydrazones combined with specific peptide analogues: looking for possible enhanced cytotoxic effects // Journal of chemical technology and metallurgy, 55 (2020), 6; 1994-1998 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1142998 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
New aroyl hydrazones combined with specific
peptide analogues: looking for possible
enhanced cytotoxic effects
Autori
Georgieva, Maya ; Balacheva, Anelia ; Detcheva, Roumiana ; Iliev, Ivan ; Galić, Nives ; Pajpanova, Tamara
Izvornik
Journal of chemical technology and metallurgy (1314-7471) 55
(2020), 6;
1994-1998
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Aroyl hydrazone derivates ; AVPI ; RGD ; anti-proliferative activity
Sažetak
Aroyl hydrazones have been intensively investigated over the last decades due to their various biological properties such as anticancer, antibacterial and antimicrobial effects. Herein, we examine the anti- proliferative effect of two new aroyl hydrazones used in a combination with AVPI- and RGD – peptides. The anti-proliferative activity is checked by MTT assay after 72h of treatment on MDA-MB-231 breast cancer cells. Though the aroyl hydrazone derivatives used as single agents shows a high activity, the combination is found not beneficial.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-4841 - Aromatski hidrazoni: sinteza, strukturna analiza, biološka aktivnost i analitička primjena (ARHYD) (Galić, Nives, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb
Profili:
Nives Galić
(autor)
