Naslov
Glycosylation and Aging

Autori
Cindrić, Ana ; Krištić, Jasminka ; Martinić Kavur, Marina ; Pezer, Marija

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
The Role of Glycosylation in Health and Disease

Urednik/ci
Lauc, Gordan ; Trbojević-Akmačić Irena

Izdavač
Springer

Grad
Cham

Godina
2021

Raspon stranica
341-373

ISBN
978-3-030-70115-4

Ključne riječi
Aging ; Biological age ; Glycosylation ; IgG N-glycome ; Inflammaging ; Plasma N-glycome

Sažetak
Human lifespan has increased significantly in the last 200 years, emphasizing our need to age healthily. Insights into molecular mechanisms of aging might allow us to slow down its rate or even revert it. Similar to aging, glycosylation is regulated by an intricate interplay of genetic and environmental factors. The dynamics of glycopattern variation during aging has been mostly explored for plasma/serum and immunoglobulin G (IgG) N-glycome, as we describe thoroughly in this chapter. In addition, we discuss the potential functional role of agalactosylated IgG glycans in aging, through modulation of inflammation level, as proposed by the concept of inflammaging. We also comment on the potential to use the plasma/serum and IgG N-glycome as a biomarker of healthy aging and on the interventions that modulate the IgG glycopattern. Finally, we discuss the current knowledge about animal models for human plasma/serum and IgG glycosylation and mention other, less explored, instances of glycopattern changes during organismal aging and cellular senescence.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA