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Pregled bibliografske jedinice broj: 1141523

DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death

Bonassi, Stefano; Ceppi, Marcello; Møller, Peter; Azqueta, Amaya; Milić, Mirta; Monica, Neri; Brunborg, Gunnar; Godschalk, Roger; Koppen, Gudrun; Langie, Sabine A. S. et al.
DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death // Scientific Reports, 11 (2021), 1; (2021) 11:16793, 11 doi:10.1038/s41598-021-95976-7 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1141523 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
(DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death)

Autori
Bonassi, Stefano ; Ceppi, Marcello ; Møller, Peter ; Azqueta, Amaya ; Milić, Mirta ; Monica, Neri ; Brunborg, Gunnar ; Godschalk, Roger ; Koppen, Gudrun ; Langie, Sabine A. S. ; Teixeira, João Paulo ; Bruzzone, Marco ; Da Silva, Juliana ; Benedetti, Danieli ; Cavallo, Delia ; Ursini, Cinzia Lucia ; Giovannelli, Lisa ; Moretti, Silvia ; Riso, Patrizia ; Del Bo’, Cristian ; Russo, Patrizia ; Dobrzyńska, Malgorzata ; Goroshinskaya, Irina A. ; Surikova, Ekaterina I. ; Staruchova, Marta ; Barančokova, Magdalena ; Volkovova, Katarina ; Kažimirova, Alena ; Smolkova, Bozena ; Laffon, Blanca ; Valdiglesias, Vanessa ; Pastor, Susana ; Marcos, Ricard ; Hernández, Alba ; Gajski, Goran ; Spremo- Potparević, Biljana ; Živković, Lada ; Boutet- Robinet, Elisa ; Perdry, Hervé ; Lebailly, Pierre ; Perez, Carlos L. ; Basaran, Nursen ; Nemeth, Zsuzsanna ; Safar, Anna ; Dusinska, Maria ; Collins, Andrew ; Anderson, Diana ; Andrade, Vanessa ; Pereira, Cristiana Costa ; Costa, Solange ; Gutzkow, Kristine B. ; Ladeira, Carina ; Moretti, Massimo ; Costa, Carla ; Orlow, Irene ; Rojas, Emilio ; Pourrut, Bertrand ; Kruszewski, Marcin ; Knasmueller, Siegfried ; Shaposhnikov, Sergey ; Žegura, Bojana ; Stopper, Helga ; for the hCOMET project

Izvornik
Scientific Reports (2045-2322) 11 (2021), 1; (2021) 11:16793, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chromosomal aberrations ; Human cancer ; Lymphocytes ; Predicts ; Frequency ; Validation ; Biomarkers ; Hallmarks ; Adducts ; Repair ; Cohort
(Chromosomal aberrations ; Human cancer ; Lymphocytes ; Predicts ; Frequency ; Validation ; Biomarkers ; Hallmarks ; Adducts ; Repair ; Cohor)

Sažetak
The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2, 403 healthy individuals (25, 978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan-Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0.001). The effect of DNA damage on survival was modelled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1.42 (1.06-1.90) for overall mortality, and 1.94 (1.04-3.59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non- communicable diseases.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Farmacija, Biotehnologija, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Goran Gajski (autor)

Avatar Url Mirta Milić (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi click.endnote.com

Citiraj ovu publikaciju:

Bonassi, Stefano; Ceppi, Marcello; Møller, Peter; Azqueta, Amaya; Milić, Mirta; Monica, Neri; Brunborg, Gunnar; Godschalk, Roger; Koppen, Gudrun; Langie, Sabine A. S. et al.
DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death // Scientific Reports, 11 (2021), 1; (2021) 11:16793, 11 doi:10.1038/s41598-021-95976-7 (međunarodna recenzija, članak, znanstveni)
Bonassi, S., Ceppi, M., Møller, P., Azqueta, A., Milić, M., Monica, N., Brunborg, G., Godschalk, R., Koppen, G. & Langie, S. (2021) DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death. Scientific Reports, 11 (1), (2021) 11:16793, 11 doi:10.1038/s41598-021-95976-7.
@article{article, author = {Bonassi, Stefano and Ceppi, Marcello and M\oller, Peter and Azqueta, Amaya and Mili\'{c}, Mirta and Monica, Neri and Brunborg, Gunnar and Godschalk, Roger and Koppen, Gudrun and Langie, Sabine A. S. and Teixeira, Jo\~{a}o Paulo and Bruzzone, Marco and Da Silva, Juliana and Benedetti, Danieli and Cavallo, Delia and Ursini, Cinzia Lucia and Giovannelli, Lisa and Moretti, Silvia and Riso, Patrizia and Del Bo’, Cristian and Russo, Patrizia and Dobrzy\'{n}ska, Malgorzata and Goroshinskaya, Irina A. and Surikova, Ekaterina I. and Staruchova, Marta and Baran\v{c}okova, Magdalena and Volkovova, Katarina and Ka\v{z}imirova, Alena and Smolkova, Bozena and Laffon, Blanca and Valdiglesias, Vanessa and Pastor, Susana and Marcos, Ricard and Hern\'{a}ndez, Alba and Gajski, Goran and Spremo- Potparevi\'{c}, Biljana and \v{Z}ivkovi\'{c}, Lada and Boutet- Robinet, Elisa and Perdry, Herv\'{e} and Lebailly, Pierre and Perez, Carlos L. and Basaran, Nursen and Nemeth, Zsuzsanna and Safar, Anna and Dusinska, Maria and Collins, Andrew and Anderson, Diana and Andrade, Vanessa and Pereira, Cristiana Costa and Costa, Solange and Gutzkow, Kristine B. and Ladeira, Carina and Moretti, Massimo and Costa, Carla and Orlow, Irene and Rojas, Emilio and Pourrut, Bertrand and Kruszewski, Marcin and Knasmueller, Siegfried and Shaposhnikov, Sergey and \v{Z}egura, Bojana and Stopper, Helga}, year = {2021}, pages = {11}, DOI = {10.1038/s41598-021-95976-7}, chapter = {(2021) 11:16793}, keywords = {Chromosomal aberrations, Human cancer, Lymphocytes, Predicts, Frequency, Validation, Biomarkers, Hallmarks, Adducts, Repair, Cohort}, journal = {Scientific Reports}, doi = {10.1038/s41598-021-95976-7}, volume = {11}, number = {1}, issn = {2045-2322}, title = {DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death}, keyword = {Chromosomal aberrations, Human cancer, Lymphocytes, Predicts, Frequency, Validation, Biomarkers, Hallmarks, Adducts, Repair, Cohort}, chapternumber = {(2021) 11:16793} }
@article{article, author = {Bonassi, Stefano and Ceppi, Marcello and M\oller, Peter and Azqueta, Amaya and Mili\'{c}, Mirta and Monica, Neri and Brunborg, Gunnar and Godschalk, Roger and Koppen, Gudrun and Langie, Sabine A. S. and Teixeira, Jo\~{a}o Paulo and Bruzzone, Marco and Da Silva, Juliana and Benedetti, Danieli and Cavallo, Delia and Ursini, Cinzia Lucia and Giovannelli, Lisa and Moretti, Silvia and Riso, Patrizia and Del Bo’, Cristian and Russo, Patrizia and Dobrzy\'{n}ska, Malgorzata and Goroshinskaya, Irina A. and Surikova, Ekaterina I. and Staruchova, Marta and Baran\v{c}okova, Magdalena and Volkovova, Katarina and Ka\v{z}imirova, Alena and Smolkova, Bozena and Laffon, Blanca and Valdiglesias, Vanessa and Pastor, Susana and Marcos, Ricard and Hern\'{a}ndez, Alba and Gajski, Goran and Spremo- Potparevi\'{c}, Biljana and \v{Z}ivkovi\'{c}, Lada and Boutet- Robinet, Elisa and Perdry, Herv\'{e} and Lebailly, Pierre and Perez, Carlos L. and Basaran, Nursen and Nemeth, Zsuzsanna and Safar, Anna and Dusinska, Maria and Collins, Andrew and Anderson, Diana and Andrade, Vanessa and Pereira, Cristiana Costa and Costa, Solange and Gutzkow, Kristine B. and Ladeira, Carina and Moretti, Massimo and Costa, Carla and Orlow, Irene and Rojas, Emilio and Pourrut, Bertrand and Kruszewski, Marcin and Knasmueller, Siegfried and Shaposhnikov, Sergey and \v{Z}egura, Bojana and Stopper, Helga}, year = {2021}, pages = {11}, DOI = {10.1038/s41598-021-95976-7}, chapter = {(2021) 11:16793}, keywords = {Chromosomal aberrations, Human cancer, Lymphocytes, Predicts, Frequency, Validation, Biomarkers, Hallmarks, Adducts, Repair, Cohor}, journal = {Scientific Reports}, doi = {10.1038/s41598-021-95976-7}, volume = {11}, number = {1}, issn = {2045-2322}, title = {DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death}, keyword = {Chromosomal aberrations, Human cancer, Lymphocytes, Predicts, Frequency, Validation, Biomarkers, Hallmarks, Adducts, Repair, Cohor}, chapternumber = {(2021) 11:16793} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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