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Pregled bibliografske jedinice broj: 1140364

Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates

Đulović, Azra; Burčul, Franko; Čikeš Čulić, Vedrana; Ruščić, Mirko; Brzović, Petra; Montaut, Sabine; Rollin, Patrick; Blažević, Ivica
Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates // Molecules, 26 (2021), 17; 5183, 11 doi:10.3390/molecules26175183 (međunarodna recenzija, članak, znanstveni)

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Naslov
Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates

Autori
Đulović, Azra ; Burčul, Franko ; Čikeš Čulić, Vedrana ; Ruščić, Mirko ; Brzović, Petra ; Montaut, Sabine ; Rollin, Patrick ; Blažević, Ivica

Izvornik
Molecules (1420-3049) 26 (2021), 17; 5183, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Lepidium graminifolium L. ; glucosinolates ; desulfoglucosinolates ; 3, 4, 5-trimethoxybenzyl glucosinolate ; benzyl isothiocyanate ; antiproliferative activity

Sažetak
Glucosinolates (GSLs) from Lepidium graminifolium L. were analyzed qualitatively and quantitatively by their desulfo-counterparts using UHPLC-DAD-MS/MS technique and by their volatile breakdown products- isothiocyanates (ITCs) using GC-MS analysis. Thirteen GSLs were identified with arylaliphatic as the major ones in the following order: 3-hydroxybenzyl GSL (glucolepigramin, 7), benzyl GSL (glucotropaeolin, 9), 3, 4, 5-trimethoxybenzyl GSL (11), 3-methoxyben- zyl GSL (glucolimnanthin, 12), 4-hydroxy-3, 5- dimethoxybenzyl GSL (3, 5-dimethoxysinalbin, 8), 4- hydroxybenzyl GSL (glucosinalbin, 6), 3, 4- dimethoxybenzyl GSL (10) and 2-phenylethyl GSL (gluconasturtiin, 13). GSL breakdown products obtained by hydrodistillation (HD) and CH2Cl2 extraction after hydrolysis by myrosinase for 24 h (EXT) as well as benzyl ITC were tested for their cytotoxic activity using MTT assay. Generally, EXT showed noticeable antiproliferative activity against human bladder cancer cell line UM-UC-3 and human glioblastoma cell line LN229, and can be considered as moderately active, while IC50 of benzyl ITC was 12.3 μg/mL, which can be considered as highly active.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA

Projekti:
HRZZ-IP-2016-06-1316 - Biljke kao izvor bioaktivnih sumporovih spojeva te njihova sposobnost hiperakumulacije metala (BioSMe) (Blažević, Ivica, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Kemijsko-tehnološki fakultet, Split,
Prirodoslovno-matematički fakultet, Split,
Medicinski fakultet, Split

Profili:

Avatar Url Vedrana Čikeš Čulić (autor)

Avatar Url Petra Brzović (autor)

Avatar Url Ivica Blažević (autor)

Avatar Url Franko Burčul (autor)

Avatar Url Mirko Ruščić (autor)

Avatar Url Azra Đulović (autor)

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Đulović, Azra; Burčul, Franko; Čikeš Čulić, Vedrana; Ruščić, Mirko; Brzović, Petra; Montaut, Sabine; Rollin, Patrick; Blažević, Ivica
Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates // Molecules, 26 (2021), 17; 5183, 11 doi:10.3390/molecules26175183 (međunarodna recenzija, članak, znanstveni)
Đulović, A., Burčul, F., Čikeš Čulić, V., Ruščić, M., Brzović, P., Montaut, S., Rollin, P. & Blažević, I. (2021) Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates. Molecules, 26 (17), 5183, 11 doi:10.3390/molecules26175183.
@article{article, author = {\DJulovi\'{c}, Azra and Bur\v{c}ul, Franko and \v{C}ike\v{s} \v{C}uli\'{c}, Vedrana and Ru\v{s}\v{c}i\'{c}, Mirko and Brzovi\'{c}, Petra and Montaut, Sabine and Rollin, Patrick and Bla\v{z}evi\'{c}, Ivica}, year = {2021}, pages = {11}, DOI = {10.3390/molecules26175183}, chapter = {5183}, keywords = {Lepidium graminifolium L., glucosinolates, desulfoglucosinolates, 3, 4, 5-trimethoxybenzyl glucosinolate, benzyl isothiocyanate, antiproliferative activity}, journal = {Molecules}, doi = {10.3390/molecules26175183}, volume = {26}, number = {17}, issn = {1420-3049}, title = {Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates}, keyword = {Lepidium graminifolium L., glucosinolates, desulfoglucosinolates, 3, 4, 5-trimethoxybenzyl glucosinolate, benzyl isothiocyanate, antiproliferative activity}, chapternumber = {5183} }
@article{article, author = {\DJulovi\'{c}, Azra and Bur\v{c}ul, Franko and \v{C}ike\v{s} \v{C}uli\'{c}, Vedrana and Ru\v{s}\v{c}i\'{c}, Mirko and Brzovi\'{c}, Petra and Montaut, Sabine and Rollin, Patrick and Bla\v{z}evi\'{c}, Ivica}, year = {2021}, pages = {11}, DOI = {10.3390/molecules26175183}, chapter = {5183}, keywords = {Lepidium graminifolium L., glucosinolates, desulfoglucosinolates, 3, 4, 5-trimethoxybenzyl glucosinolate, benzyl isothiocyanate, antiproliferative activity}, journal = {Molecules}, doi = {10.3390/molecules26175183}, volume = {26}, number = {17}, issn = {1420-3049}, title = {Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates}, keyword = {Lepidium graminifolium L., glucosinolates, desulfoglucosinolates, 3, 4, 5-trimethoxybenzyl glucosinolate, benzyl isothiocyanate, antiproliferative activity}, chapternumber = {5183} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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