Pregled bibliografske jedinice broj: 1139517
An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex
An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex // GERMS, 11 (2021), 2; 199-210 doi:10.18683/germs.2021.1257 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1139517 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
An outbreak of ertapenem resistant,
carbapenemase-negative and porin-deficient
ESBL-producing Klebsiella pneumoniae complex
Autori
Matovina, Mihaela ; Abram, Maja ; Repac-Antić, Davorka ; Knežević, Samira ; Bubonja-Šonje, Marina
Izvornik
GERMS (2248-2997) 11
(2021), 2;
199-210
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
ertapenem ; drug resistance ; Klebsiella pneumoniae ; molecular epidemiology ; outbreak
Sažetak
Introduction: Carbapenem-resistant Klebsiella pneumoniae is an emerging healthcare-associated pathogen with dynamic molecular epidemiology. This study presents a retrospective analysis of the distribution and antibiotic resistance patterns of ertapenem-resistant ESBL-producing K. pneumoniae strains recovered during an outbreak from 2012 to 2014 in a Croatian University hospital. Methods We aimed to estimate genetic relatedness of clinical isolates and underlying mechanisms that conferred the ertapenem- resistant phenotype. Results: Expression analysis of genes involved in the antibiotic resistance showed reduced expression of major non-selective porin channel OmpK35. Reduced expression of OmpK36 porin channel in isolates resistant to at least one more carbapenem, apart from the ertapenem, was found to a lesser degree. Pulsed-field gel electrophoresis analysis of genomic DNA revealed that almost all isolates belonged to the same genetic clone. Conclusions: Caution regarding ertapenem- resistant, carbapenemase-negative porin- deficient mutants of K. pneumoniae is required as they are widespread, and under selective pressure this could result in a local clonal outbreak.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
--uniri-biomed-18-215 - Proširenost i klinički značaj HBs antigenih mutanti virusa hepatitisa B (Bubonja Šonje, Marina) ( CroRIS)
--uniri-biomed-18-277 - Bakterijska patogeneza - od istraživanja do kliničke primjene (Abram, Maja) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka,
Institut "Ruđer Bošković", Zagreb,
Klinički bolnički centar Rijeka
Profili:
Maja Abram
(autor)
Davorka Repac Antić
(autor)
Marina Bubonja Šonje
(autor)
Mihaela Matovina
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Emerging Sources Citation Index (ESCI)
- Scopus