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Pregled bibliografske jedinice broj: 1139517

An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex


Matovina, Mihaela; Abram, Maja; Repac-Antić, Davorka; Knežević, Samira; Bubonja-Šonje, Marina
An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex // GERMS, 11 (2021), 2; 199-210 doi:10.18683/germs.2021.1257 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1139517 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex

Autori
Matovina, Mihaela ; Abram, Maja ; Repac-Antić, Davorka ; Knežević, Samira ; Bubonja-Šonje, Marina

Izvornik
GERMS (2248-2997) 11 (2021), 2; 199-210

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ertapenem ; drug resistance ; Klebsiella pneumoniae ; molecular epidemiology ; outbreak

Sažetak
Introduction: Carbapenem-resistant Klebsiella pneumoniae is an emerging healthcare-associated pathogen with dynamic molecular epidemiology. This study presents a retrospective analysis of the distribution and antibiotic resistance patterns of ertapenem-resistant ESBL-producing K. pneumoniae strains recovered during an outbreak from 2012 to 2014 in a Croatian University hospital. Methods We aimed to estimate genetic relatedness of clinical isolates and underlying mechanisms that conferred the ertapenem- resistant phenotype. Results: Expression analysis of genes involved in the antibiotic resistance showed reduced expression of major non-selective porin channel OmpK35. Reduced expression of OmpK36 porin channel in isolates resistant to at least one more carbapenem, apart from the ertapenem, was found to a lesser degree. Pulsed-field gel electrophoresis analysis of genomic DNA revealed that almost all isolates belonged to the same genetic clone. Conclusions: Caution regarding ertapenem- resistant, carbapenemase-negative porin- deficient mutants of K. pneumoniae is required as they are widespread, and under selective pressure this could result in a local clonal outbreak.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
--uniri-biomed-18-215 - Proširenost i klinički značaj HBs antigenih mutanti virusa hepatitisa B (Bubonja Šonje, Marina) ( CroRIS)
--uniri-biomed-18-277 - Bakterijska patogeneza - od istraživanja do kliničke primjene (Abram, Maja) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka,
Institut "Ruđer Bošković", Zagreb,
Klinički bolnički centar Rijeka

Poveznice na cjeloviti tekst rada:

doi www.germs.ro fulir.irb.hr

Citiraj ovu publikaciju:

Matovina, Mihaela; Abram, Maja; Repac-Antić, Davorka; Knežević, Samira; Bubonja-Šonje, Marina
An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex // GERMS, 11 (2021), 2; 199-210 doi:10.18683/germs.2021.1257 (međunarodna recenzija, članak, znanstveni)
Matovina, M., Abram, M., Repac-Antić, D., Knežević, S. & Bubonja-Šonje, M. (2021) An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex. GERMS, 11 (2), 199-210 doi:10.18683/germs.2021.1257.
@article{article, author = {Matovina, Mihaela and Abram, Maja and Repac-Anti\'{c}, Davorka and Kne\v{z}evi\'{c}, Samira and Bubonja-\v{S}onje, Marina}, year = {2021}, pages = {199-210}, DOI = {10.18683/germs.2021.1257}, keywords = {ertapenem, drug resistance, Klebsiella pneumoniae, molecular epidemiology, outbreak}, journal = {GERMS}, doi = {10.18683/germs.2021.1257}, volume = {11}, number = {2}, issn = {2248-2997}, title = {An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex}, keyword = {ertapenem, drug resistance, Klebsiella pneumoniae, molecular epidemiology, outbreak} }
@article{article, author = {Matovina, Mihaela and Abram, Maja and Repac-Anti\'{c}, Davorka and Kne\v{z}evi\'{c}, Samira and Bubonja-\v{S}onje, Marina}, year = {2021}, pages = {199-210}, DOI = {10.18683/germs.2021.1257}, keywords = {ertapenem, drug resistance, Klebsiella pneumoniae, molecular epidemiology, outbreak}, journal = {GERMS}, doi = {10.18683/germs.2021.1257}, volume = {11}, number = {2}, issn = {2248-2997}, title = {An outbreak of ertapenem resistant, carbapenemase-negative and porin-deficient ESBL-producing Klebsiella pneumoniae complex}, keyword = {ertapenem, drug resistance, Klebsiella pneumoniae, molecular epidemiology, outbreak} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)
  • Scopus


Citati:





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