Pregled bibliografske jedinice broj: 1139340
Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study
Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study // Frontiers in psychiatry, 8 (2017), 277, 9 doi:10.3389/fpsyt.2017.00277 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1139340 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Lower Choline-Containing Metabolites/Creatine
(Cr) Rise and Failure to Sustain NA/Cr Levels
in the Dorsolateral Prefrontal Cortex Are
Associated with Depressive Episode Recurrence
under Maintenance Therapy: A Proton Magnetic
Resonance Spectroscopy Retrospective Cohort
Study
Autori
Henigsberg, Neven ; Šarac, Helena ; Radoš, Marko ; Radoš, Milan ; Ozretić, David ; Foro, Tamara ; Erdeljić Turk, Viktorija ; Hrabač, Pero ; Bajs Janović, Maja ; Rak, Benedict ; Kalember, Petra
Izvornik
Frontiers in psychiatry (1664-0640) 8
(2017);
277, 9
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
depression, recurrence, maintenance therapy, antidepressants, magnetic resonance spectroscopy
Sažetak
Background: The aim of this study was to evaluate the relationship between changes in proton magnetic resonance spectroscopy (1H-MRS) parameters at the start of the index episode recovery phase and at recurrence in patients with recurrent depression who were treated with prolonged maintenance therapy. Methods: 1H-MRS parameters were analyzed in 48 patients with recurrent depression who required maintenance therapy with antidepressant medication prescribed by a psychiatrist and who continued with the same antidepressant during the maintenance phase, either to recurrence of depression, completion of the 10-year observation period, or the start of the withdrawal phase (tapering- off antidepressant). N-acetylaspartate (NAA), choline-containing metabolites (Cho), creatine (Cr), and glutamine/glutamate were measured at the start of the recovery phase and 6 months later. Results: Recurrent depressive episodes occurred in 20 patients. These individuals had a smaller increase in Cho/Cr after the beginning of the recovery phase compared to the non-recurrent patient group and also exhibited a decreased NAA/Cr ratio. Conclusion: Sustainable NAA and increased Cho levels at the onset of the recovery phase of the index episode are early markers of antidepressant effectiveness associated with a lower risk of major depressive disorder recurrence. The NAA and Cho changes in the non-recurrent group may be attributable to increased brain resilience, contrary to the transient temporal effect observed in subjects who experienced a depressive episode.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Milan Radoš
(autor)
Maja Bajs Janović
(autor)
Marko Radoš
(autor)
David Ozretić
(autor)
Helena Šarac
(autor)
Neven Henigsberg
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Emerging Sources Citation Index (ESCI)
- Scopus