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Pregled bibliografske jedinice broj: 1139340

Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study


Henigsberg, Neven; Šarac, Helena; Radoš, Marko; Radoš, Milan; Ozretić, David; Foro, Tamara; Erdeljić Turk, Viktorija; Hrabač, Pero; Bajs Janović, Maja; Rak, Benedict; Kalember, Petra
Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study // Frontiers in psychiatry, 8 (2017), 277, 9 doi:10.3389/fpsyt.2017.00277 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1139340 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study

Autori
Henigsberg, Neven ; Šarac, Helena ; Radoš, Marko ; Radoš, Milan ; Ozretić, David ; Foro, Tamara ; Erdeljić Turk, Viktorija ; Hrabač, Pero ; Bajs Janović, Maja ; Rak, Benedict ; Kalember, Petra

Izvornik
Frontiers in psychiatry (1664-0640) 8 (2017); 277, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
depression, recurrence, maintenance therapy, antidepressants, magnetic resonance spectroscopy

Sažetak
Background: The aim of this study was to evaluate the relationship between changes in proton magnetic resonance spectroscopy (1H-MRS) parameters at the start of the index episode recovery phase and at recurrence in patients with recurrent depression who were treated with prolonged maintenance therapy. Methods: 1H-MRS parameters were analyzed in 48 patients with recurrent depression who required maintenance therapy with antidepressant medication prescribed by a psychiatrist and who continued with the same antidepressant during the maintenance phase, either to recurrence of depression, completion of the 10-year observation period, or the start of the withdrawal phase (tapering- off antidepressant). N-acetylaspartate (NAA), choline-containing metabolites (Cho), creatine (Cr), and glutamine/glutamate were measured at the start of the recovery phase and 6 months later. Results: Recurrent depressive episodes occurred in 20 patients. These individuals had a smaller increase in Cho/Cr after the beginning of the recovery phase compared to the non-recurrent patient group and also exhibited a decreased NAA/Cr ratio. Conclusion: Sustainable NAA and increased Cho levels at the onset of the recovery phase of the index episode are early markers of antidepressant effectiveness associated with a lower risk of major depressive disorder recurrence. The NAA and Cho changes in the non-recurrent group may be attributable to increased brain resilience, contrary to the transient temporal effect observed in subjects who experienced a depressive episode.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Henigsberg, Neven; Šarac, Helena; Radoš, Marko; Radoš, Milan; Ozretić, David; Foro, Tamara; Erdeljić Turk, Viktorija; Hrabač, Pero; Bajs Janović, Maja; Rak, Benedict; Kalember, Petra
Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study // Frontiers in psychiatry, 8 (2017), 277, 9 doi:10.3389/fpsyt.2017.00277 (međunarodna recenzija, članak, znanstveni)
Henigsberg, N., Šarac, H., Radoš, M., Radoš, M., Ozretić, D., Foro, T., Erdeljić Turk, V., Hrabač, P., Bajs Janović, M., Rak, B. & Kalember, P. (2017) Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study. Frontiers in psychiatry, 8, 277, 9 doi:10.3389/fpsyt.2017.00277.
@article{article, author = {Henigsberg, Neven and \v{S}arac, Helena and Rado\v{s}, Marko and Rado\v{s}, Milan and Ozreti\'{c}, David and Foro, Tamara and Erdelji\'{c} Turk, Viktorija and Hraba\v{c}, Pero and Bajs Janovi\'{c}, Maja and Rak, Benedict and Kalember, Petra}, year = {2017}, pages = {9}, DOI = {10.3389/fpsyt.2017.00277}, chapter = {277}, keywords = {depression, recurrence, maintenance therapy, antidepressants, magnetic resonance spectroscopy}, journal = {Frontiers in psychiatry}, doi = {10.3389/fpsyt.2017.00277}, volume = {8}, issn = {1664-0640}, title = {Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study}, keyword = {depression, recurrence, maintenance therapy, antidepressants, magnetic resonance spectroscopy}, chapternumber = {277} }
@article{article, author = {Henigsberg, Neven and \v{S}arac, Helena and Rado\v{s}, Marko and Rado\v{s}, Milan and Ozreti\'{c}, David and Foro, Tamara and Erdelji\'{c} Turk, Viktorija and Hraba\v{c}, Pero and Bajs Janovi\'{c}, Maja and Rak, Benedict and Kalember, Petra}, year = {2017}, pages = {9}, DOI = {10.3389/fpsyt.2017.00277}, chapter = {277}, keywords = {depression, recurrence, maintenance therapy, antidepressants, magnetic resonance spectroscopy}, journal = {Frontiers in psychiatry}, doi = {10.3389/fpsyt.2017.00277}, volume = {8}, issn = {1664-0640}, title = {Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study}, keyword = {depression, recurrence, maintenance therapy, antidepressants, magnetic resonance spectroscopy}, chapternumber = {277} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
    • Emerging Sources Citation Index (ESCI)
  • Scopus


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