Pregled bibliografske jedinice broj: 1139335
Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study
Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study // Croatian medical journal, 59 (2018), 5; 244-252 doi:10.3325/cmj.2018.59.244 (međunarodna recenzija, članak, znanstveni)
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Naslov
Choline and N-acetyl aspartate levels in the
dorsolateral prefrontal cortex at the beginning
of the recovery phase as markers of increased
risk for depressive episode recurrence under
different duration of maintenance therapy and
after it: a retrospective cohort study
Autori
Henigsberg, Neven ; Savić, Aleksandar ; Radoš, Marko ; Šarac, Helena ; Radoš, Milan ; Ozretić, David ; Bajs Janović, Maja ; Erdeljić Turk, Viktorija ; Šečić, Ana ; Kalember, Petra ; Hrabač, Pero
Izvornik
Croatian medical journal (0353-9504) 59
(2018), 5;
244-252
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
depression ; antidepressant ; therapy ; recurrence ; recovery ; magnetic resonance spectroscopy ; NAA ; Cho ; Glx
Sažetak
Aim To evaluate the relationship between the dynamics of proton magnetic resonance spectroscopy (1H-MRS) brain metabolite levels at the beginning of the recovery phase of the index depressive episode and the time to the recurrence of depression. Methods This retrospective cohort study analyzed the changes in N-acetyl aspartate (NAA), choline (Cho), and glutamate- glutamine in 48 patients with recurrent depression treated with maintenance antidepressant monotherapy at a stable dose. 1H-MRS was performed at the start of the recovery phase and 6 months later. 1H-MRS parameters, index episode descriptors, and depressive disorder course were analyzed by Cox proportional hazards model. Results NAA and Cho decrease six months after the beginning of the recovery period were time-independent risk factors for depressive episode recurrence. Hazard ratio associated with NAA decrease was 2.02 (95% confidence interval 1.06- 3.84) and that associated with Cho decrease was 2.06 (95% confidence interval 1.02-4.17). These changes were not related to symptoms severity, as Montgomery- Asberg Depression Scale score remained generally unchanged (mean -0.01 ; standard deviation 1.6) over the first 6 months of recovery. Conclusion Patients receiving maintenance antidepressant therapy after recovery who experience a decrease in NAA or Cho levels early in the recovery phase have a double risk of depressive episode recurrence. Sustained NAA and Cho levels at the beginning of the recovery phase may indicate increased brain resilience conferred by antidepressant therapy, while NAA and Cho decrease may indicate only the trait-related temporal effect of therapy in another stratum of patients.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
--KK.01.1.1.01.0007 - Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi (ZCI Neuro) (Judaš, Miloš) ( CroRIS)
--IP-2014-09-2979 - Multimodalni pristup liječenju i dugoročnom praćenju tijeka depresivnog poremećaja metodom magnetske rezonancije (MODERN) (Henigsberg, Neven) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Milan Radoš
(autor)
Aleksandar Savić
(autor)
Maja Bajs Janović
(autor)
Marko Radoš
(autor)
David Ozretić
(autor)
Helena Šarac
(autor)
Neven Henigsberg
(autor)
Poveznice na cjeloviti tekst rada:
Pristup cjelovitom tekstu rada doi hrcak.srce.hr www.ncbi.nlm.nih.govCitiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE