Naslov
The Role of Salivary and Serum Ca125 and Routine Blood Tests in Patients with Ovarian Malignancies

Autori
Vuković, Ante ; Kuna, Krunoslav ; Lončar Brzak, Božana ; Vučičević Boras, †Vanja ; Šeparović, Robert ; Šekerija, Mario ; Šumilin, Lada ; Vidranski, Valentina

Izvornik
Acta clinica Croatica (0353-9466) 60 (2021), 1; 55-62

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Malignancies ; CA125 antigen ; Blood tests

Sažetak
The use of routine blood tests has recently been shown to be promising in deter- mining disease- free and overall survival in patients with various malignancies, and also in gyneco- logic malignancies. The aim of this study was to evaluate whether salivary and serum CA125 levels correlate and whether salivary and serum CA125, C- reactive protein and routine blood tests might serve as a prognostic factor in malignant ovarian tumors, and whether they might differentiate be- tween benign and malignant ovarian tumors. A total of 98 women were included (48 with benign ovarian tumors and 50 with malignant ovarian tumors), in whom routine blood tests were made and salivary and serum CA125 levels were determined by use of ELISA. Increase in serum CA125 and amylase decreased overall survival, whereas increase in salivary CA125, potassium levels and hemoglo- bin increased overall survival. Significant correlation of serum CA125 and C-reactive protein was found in the group with malignant tumors. In conclusion, significant increase in the levels of serum CA125 and amylase correlated with decreased survival, whereas increased salivary CA125, hemoglo- bin and potassium levels significantly correlated with increased survival.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA