Bithiophene-Cored, mono-, bis-, and tris-(Trimethylammonium)-Substituted, bis-Triarylborane Chromophores: Effect of the Number and Position of Charges on Cell Imaging and DNA/RNA Sensing

Berger, Sarina M.; Rühe, Jessica; Schwarzmann, Johannes; Phillipps, Alexandra; Richard, Ann-Katrin; Ferger, Matthias; Krummenacher, Ivo; Tumir, Lidija-Marija; Ban, Željka; Crnolatac, Ivo; Majhen, Dragomira; Barišić, Ivan; Piantanida, Ivo; Schleier, Domenik; Griesbeck, Stefanie; Friedrich, Alexandra; Braunschweig, Holger; Marder, Todd B.

doi:10.1002/chem.202102308

Pregled bibliografske jedinice broj: 1139192

Bithiophene-Cored, mono-, bis-, and tris-(Trimethylammonium)- Substituted, bis-Triarylborane Chromophores: Effect of the Number and Position of Charges on Cell Imaging and DNA/RNA Sensing

Berger, Sarina M.; Rühe, Jessica; Schwarzmann, Johannes; Phillipps, Alexandra; Richard, Ann-Katrin; Ferger, Matthias; Krummenacher, Ivo; Tumir, Lidija-Marija; Ban, Željka; Crnolatac, Ivo et al.

Bithiophene-Cored, mono-, bis-, and tris-(Trimethylammonium)- Substituted, bis-Triarylborane Chromophores: Effect of the Number and Position of Charges on Cell Imaging and DNA/RNA Sensing // Chemistry : a European journal, 27 (2021), 14057-14072 doi:10.1002/chem.202102308 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1139192 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bithiophene-Cored, mono-, bis-, and tris-(Trimethylammonium)- Substituted, bis-Triarylborane Chromophores: Effect of the Number and Position of Charges on Cell Imaging and DNA/RNA Sensing

Autori
Berger, Sarina M. ; Rühe, Jessica ; Schwarzmann, Johannes ; Phillipps, Alexandra ; Richard, Ann-Katrin ; Ferger, Matthias ; Krummenacher, Ivo ; Tumir, Lidija-Marija ; Ban, Željka ; Crnolatac, Ivo ; Majhen, Dragomira ; Barišić, Ivan ; Piantanida, Ivo ; Schleier, Domenik ; Griesbeck, Stefanie ; Friedrich, Alexandra ; Braunschweig, Holger ; Marder, Todd B.

Izvornik
Chemistry : a European journal (0947-6539) 27 (2021); 14057-14072

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
boron ; bioimaging ; luminescence ; singlet oxygen ; nucleic acid

Sažetak
The synthesis, photophysical, and electrochemical properties of selectively mono-, bis- and tris-dimethylamino- and trimethylammonium-substituted bis-triarylborane bithiophene chromophores are presented along with the water solubility and singlet oxygen sensitizing efficiency of the cationic compounds Cat1+, Cat2+, Cat(i)2+, and Cat3+. Comparison with the mono- triarylboranes reveals the large influence of the bridging unit on the properties of the bistriarylboranes, especially those of the cationic compounds. Based on these preliminary investigations, the interactions of Cat1+, Cat2+, Cat(i)2+, and Cat3+ with DNA, RNA, and DNApore were investigated in buffered solutions. The same compounds were investigated for their ability to enter and localize within organelles of human lung carcinoma (A549) and normal lung (WI38) cells showing that not only the number of charges but also their distribution over the chromophore influences interactions and staining properties.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA

Projekti:
HRZZ-IP-2018-01-5475 - Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina (BioMultiChromoProbes) (Piantanida, Ivo, HRZZ - 2018-01) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Lidija-Marija Tumir (autor)