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Pregled bibliografske jedinice broj: 1138957

SARS-CoV-2 seroprevalence and neutralizing antibody response after the first and second COVID-19 pandemic wave in Croatia


Vilibić-Čavlek, Tatjana; Stevanović, Vladimir; Ilić, Maja; Barbić, Ljubo; Capak, Krunoslav; Tabain, Irena; Leniček Krleža, Jasna; Ferenc, Thomas; Hruškar, Željka; Zrinski Topić, Renata et al.
SARS-CoV-2 seroprevalence and neutralizing antibody response after the first and second COVID-19 pandemic wave in Croatia // Pathogens, 10 (2021), 6; 774, 12 doi:10.3390/pathogens10060774 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1138957 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
SARS-CoV-2 seroprevalence and neutralizing antibody response after the first and second COVID-19 pandemic wave in Croatia

Autori
Vilibić-Čavlek, Tatjana ; Stevanović, Vladimir ; Ilić, Maja ; Barbić, Ljubo ; Capak, Krunoslav ; Tabain, Irena ; Leniček Krleža, Jasna ; Ferenc, Thomas ; Hruškar, Željka ; Zrinski Topić, Renata ; Kaliterna, Vanja ; Antolović-Požgain, Arlen ; Kučinar, Jasmina ; Košćak, Iva ; Mayer, Dijana ; Sviben, Mario ; Antolašić, Ljiljana ; Milašinčić, Ljiljana ; Bučić, Lovro ; Ferenčak, Ivana ; Kaić, Bernard

Izvornik
Pathogens (2076-0817) 10 (2021), 6; 774, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COVID-19 ; SARS-CoV-2 ; seroprevalence ; ELISA ; VNT ; Croatia
(DCOVID-19 ; SARS-CoV-2 ; seroprevalence ; ELISA ; VNT ; Croatia)

Sažetak
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus with a pandemic spread. So far, a total of 349, 910 SARS-CoV-2 cases and 7687 deaths were reported in Croatia. We analyzed the seroprevalence and neutralizing (NT) antibody response in the Croatian general population after the first (May–July 2020) and second (December 2020–February 2021) pandemic wave. Initial serological testing was performed using a commercial ELISA, with confirmation of reactive samples by a virus neutralization test (VNT). A significant difference in the overall seroprevalence rate was found after the first (ELISA 2.2%, VNT 0.2%) and second waves (ELISA 25.1%, VNT 18.7%). Seropositive individuals were detected in all age groups, with significant differences according to age. The lowest prevalence of NT antibodies was documented in the youngest (<10 years ; 16.1%) and the oldest (60–69/70+ years ; 16.0% and 12.8%, respectively) age groups. However, these age groups showed the highest median NT titers (32–64). In other groups, seropositivity varied from 19.3% to 21.5%. A significant weak positive correlation between binding antibody level as detected by ELISA and VNT titer (rho = 0.439, p < 0.001) was observed. SARS-CoV-2 NT antibody titers seem to be age-related, with the highest NT activity in children under 10 years and individuals above 50 years.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Ustanove:
Hrvatski zavod za javno zdravstvo,
Klinička bolnica "Merkur",
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinika za dječje bolesti

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Vilibić-Čavlek, Tatjana; Stevanović, Vladimir; Ilić, Maja; Barbić, Ljubo; Capak, Krunoslav; Tabain, Irena; Leniček Krleža, Jasna; Ferenc, Thomas; Hruškar, Željka; Zrinski Topić, Renata et al.
SARS-CoV-2 seroprevalence and neutralizing antibody response after the first and second COVID-19 pandemic wave in Croatia // Pathogens, 10 (2021), 6; 774, 12 doi:10.3390/pathogens10060774 (međunarodna recenzija, članak, znanstveni)
Vilibić-Čavlek, T., Stevanović, V., Ilić, M., Barbić, L., Capak, K., Tabain, I., Leniček Krleža, J., Ferenc, T., Hruškar, Ž. & Zrinski Topić, R. (2021) SARS-CoV-2 seroprevalence and neutralizing antibody response after the first and second COVID-19 pandemic wave in Croatia. Pathogens, 10 (6), 774, 12 doi:10.3390/pathogens10060774.
@article{article, author = {Vilibi\'{c}-\v{C}avlek, Tatjana and Stevanovi\'{c}, Vladimir and Ili\'{c}, Maja and Barbi\'{c}, Ljubo and Capak, Krunoslav and Tabain, Irena and Leni\v{c}ek Krle\v{z}a, Jasna and Ferenc, Thomas and Hru\v{s}kar, \v{Z}eljka and Zrinski Topi\'{c}, Renata and Kaliterna, Vanja and Antolovi\'{c}-Po\v{z}gain, Arlen and Ku\v{c}inar, Jasmina and Ko\v{s}\'{c}ak, Iva and Mayer, Dijana and Sviben, Mario and Antola\v{s}i\'{c}, Ljiljana and Mila\v{s}in\v{c}i\'{c}, Ljiljana and Bu\v{c}i\'{c}, Lovro and Feren\v{c}ak, Ivana and Kai\'{c}, Bernard}, year = {2021}, pages = {12}, DOI = {10.3390/pathogens10060774}, chapter = {774}, keywords = {COVID-19, SARS-CoV-2, seroprevalence, ELISA, VNT, Croatia}, journal = {Pathogens}, doi = {10.3390/pathogens10060774}, volume = {10}, number = {6}, issn = {2076-0817}, title = {SARS-CoV-2 seroprevalence and neutralizing antibody response after the first and second COVID-19 pandemic wave in Croatia}, keyword = {COVID-19, SARS-CoV-2, seroprevalence, ELISA, VNT, Croatia}, chapternumber = {774} }
@article{article, author = {Vilibi\'{c}-\v{C}avlek, Tatjana and Stevanovi\'{c}, Vladimir and Ili\'{c}, Maja and Barbi\'{c}, Ljubo and Capak, Krunoslav and Tabain, Irena and Leni\v{c}ek Krle\v{z}a, Jasna and Ferenc, Thomas and Hru\v{s}kar, \v{Z}eljka and Zrinski Topi\'{c}, Renata and Kaliterna, Vanja and Antolovi\'{c}-Po\v{z}gain, Arlen and Ku\v{c}inar, Jasmina and Ko\v{s}\'{c}ak, Iva and Mayer, Dijana and Sviben, Mario and Antola\v{s}i\'{c}, Ljiljana and Mila\v{s}in\v{c}i\'{c}, Ljiljana and Bu\v{c}i\'{c}, Lovro and Feren\v{c}ak, Ivana and Kai\'{c}, Bernard}, year = {2021}, pages = {12}, DOI = {10.3390/pathogens10060774}, chapter = {774}, keywords = {DCOVID-19, SARS-CoV-2, seroprevalence, ELISA, VNT, Croatia}, journal = {Pathogens}, doi = {10.3390/pathogens10060774}, volume = {10}, number = {6}, issn = {2076-0817}, title = {SARS-CoV-2 seroprevalence and neutralizing antibody response after the first and second COVID-19 pandemic wave in Croatia}, keyword = {DCOVID-19, SARS-CoV-2, seroprevalence, ELISA, VNT, Croatia}, chapternumber = {774} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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