Naslov
Acquired Factor V Inhibitor: A Case Report

Autori
Gaćina, Petar ; Kušec, Rajko ; Čaržavec, Dubravka ; Raić, Biserka ; Stančić, Vladimir

Izvornik
Acta clinica Croatica (0353-9466) 45 (2006), 3; 199-201

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Blood coagulation factors - antagonists and inhibitors ; Antibodies - immunology ; Blood coagulation disorders - immunology ; Factor V -...

Sažetak
A 19-year-old asymptomatic man who was admitted to our hospital for investigation of prolonged screening coagulation assays, prothrombin time and activated partial thromboplastin time is presented. Further evaluation revealed factor V deficiency and the presence of specific factor V inhibitors. The appearance of these inhibitors may be associated with administration of some antibiotics, topical bovine thrombin preparations containing bovine factor V during surgical or dental procedures, after blood transfusions and in patients with malignancy or autoimmune diseases. Factor V inhibitors may also develop spontaneously in patients without any clearly identifiable cause. Our patient had no personal or family history of bleeding tendency or thromboembolic event. There is a general consensus that asymptomatic patients should not be treated regardless of their inhibitor titer and residual factor V levels.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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