Naslov
Reprogramming of tyrosine phosphorylation regulated signalling pathways by HPV oncoproteins

Autori
Szalmás, Anita ; Tomaić, Vjekoslav ; Massimi, Paola ; Gyöngyösi, Eszter ; Kónya, József ; Banks, Lawrence

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 5th Central European Forum for Microbiology, in Acta Microbiologica et Immunologica Hungarica, 64(Supplement 1) / - : Akadémiai Kiadó, 2017, 171-172

Skup
5th Central European Forum for Microbiology

Mjesto i datum
Keszthely, Mađarska, 18.10.2017. - 20.10.2017

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HPV E7 ; PTPN14 ; PTPN21

Sažetak
Activation of signaling pathways ensuring cell growth are essential for the proliferative competence of human papillomavirus (HPV) infected cells. Kinases and phosphatases are the key regulators of cellular growth control pathways. Recently identified cellular targets of HPV E7 are certain cytoplasmic protein tyrosine kinases and phosphatases, such as Src, PTPN14, and PTPN21, which have been linked to the control of multiple cellular growth pathways. We showed that the E7 proteins of both high-risk and low-risk mucosal HPV types can interact with certain non-receptor kinases and phosphatases. These interactions can happen independently of pRb regulation. We also showed that E7 can influence the stability of these regulatory proteins, for example by inducing proteasome mediated degradation of certain cytoplasmic phosphatases.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA