Pregled bibliografske jedinice broj: 1137828
SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells
SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells // Scientific reports, 11 (2021), 1; 14880, 11 doi:10.1038/s41598-021-93971-6 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1137828 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells
Autori
Trnski, Diana ; Sabol, Maja ; Tomić, Sanja ; Štefanac, Ivan ; Mrčela, Milanka ; Musani, Vesna ; Rinčić, Nikolina ; Kurtović, Matea ; Petrić, Tina ; Levanat, Sonja ; Ozretić, Petar
Izvornik
Scientific reports (2045-2322) 11
(2021), 1;
14880, 11
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
prostate cancer ; HH-GLI signaling ; SHH-N ; androgen receptor
Sažetak
Prostate cancer is the second most frequent cancer diagnosed in men worldwide. Localized disease can be successfully treated, but advanced cases are more problematic. After initial effectiveness of androgen deprivation therapy, resistance quickly occurs. Therefore, we aimed to investigate the role of Hedgehog-GLI (HH-GLI) signaling in sustaining androgen-independent growth of prostate cancer cells. We found various modes of HH-GLI signaling activation in prostate cancer cells depending on androgen availability. When androgen was not deprived, we found evidence of non-canonical SMO signaling through the SRC kinase. After short-term androgen deprivation canonical HH-GLI signaling was activated, but we found little evidence of canonical HH-GLI signaling activity in androgen-independent prostate cancer cells. We show that in androgen-independent cells the pathway ligand, SHH-N, non-canonically binds to the androgen receptor through its cholesterol modification. Inhibition of this interaction leads to androgen receptor signaling downregulation. This implies that SHH-N activates the androgen receptor and sustains androgen-independence. Targeting this interaction might prove to be a valuable strategy for advanced prostate cancer treatment. Also, other non-canonical aspects of this signaling pathway should be investigated in more detail and considered when developing potential therapies.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2018-01-2936 - Biološka važnost dipeptidil peptidaze III i njezin utjecaj na zdravlje čovjeka (DPP3BioRe) (Tomić, Sanja, HRZZ - 2018-01) ( CroRIS)
HRZZ-IP-2018-01-4889 - Regulacija GLI koda u tumorima ovisnim o BRAF/NRAS mutacijama (GLIcode) (Sabol, Maja, HRZZ - 2018-01) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek
Profili:
Tina Petrić (autor)
Petar Ozretić (autor)
Vesna Musani (autor)
Sonja Levanat (autor)
Milanka Mrčela (autor)
Diana Trnski (autor)
IVAN ŠTEFANAC (autor)
Sanja Tomić (autor)
Matea Kurtović (autor)
Nikolina Piteša (autor)
Maja Sabol (autor)
Poveznice na cjeloviti tekst rada:
Pristup cjelovitom tekstu rada doi www.nature.com doi.org fulir.irb.hrCitiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE