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Pregled bibliografske jedinice broj: 1137623

Glycomics for type 2 diabetes biomarker discovery: promise of immunoglobulin G subclass-specific fragment crystallizable N-glycosylation in the Uyghur population


Liu, Jiaonan; Dolikun, Mamatyusupu; Štambuk, Jerko; Trbojević-Akmačić, Irena; Zhang, Jie; Zhang, Jinxia; Wang, Hao; Meng, Xiaoni; Razdorov, Genadij; Menon, Desmond et al.
Glycomics for type 2 diabetes biomarker discovery: promise of immunoglobulin G subclass-specific fragment crystallizable N-glycosylation in the Uyghur population // Omics-a journal of integrative biology, 23 (2019), 12; 640-648 doi:10.1089/omi.2019.0052 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1137623 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Glycomics for type 2 diabetes biomarker discovery: promise of immunoglobulin G subclass-specific fragment crystallizable N-glycosylation in the Uyghur population

Autori
Liu, Jiaonan ; Dolikun, Mamatyusupu ; Štambuk, Jerko ; Trbojević-Akmačić, Irena ; Zhang, Jie ; Zhang, Jinxia ; Wang, Hao ; Meng, Xiaoni ; Razdorov, Genadij ; Menon, Desmond ; Zheng, Deqiang ; Wu, Lijuan ; Wang, Youxin ; Song, Manshu ; Lauc, Gordan ; Wang, Wei

Izvornik
Omics-a journal of integrative biology (1536-2310) 23 (2019), 12; 640-648

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
type 2 diabetes mellitus ; glycomics ; biomarkers ; personalized medicine ; IgG ; subclass-specific Fc glycosylation ; Uyghur population

Sažetak
Aberrant immunoglobulin G (IgG) N-glycosylation offers new prospects to detect changes in cell metabolism and by extension, for biomarker discovery in type 2 diabetes mellitus (T2DM). However, past studies did not analyze the individual IgG subclasses in relation to T2DM pathophysiology. We report here original findings through a comparison of the IgG subclass-specific fragment crystallizable (Fc) glycan biosignatures in 115 T2DM patients with 122 healthy controls within the Uyghur population in China. IgG Fc glycosylation profiles were analyzed using nano- liquid chromatography–mass spectrometry to exclude changes attributed to fragment antigen binding N- glycosylation. After correction for clinical covariates, 27 directly measured and 4 derived glycan traits of the IgG subclass-specific N- glycopeptides were significantly associated with T2DM. Furthermore, we observed in T2DM a decrease in bisecting N-acetylglucosamine of IgG2 and agalactosylation of IgG4, and an increase in sialylation of IgG4 and digalactosylation of IgG2. Classification model based on IgG subclass- specific N-glycan traits was able to distinguish patients with T2DM from controls with an area under the receiver operating characteristic curve of 0.927 (95% confidence interval 0.894–0.960, p < 0.001). In conclusion, a robust association between the IgG subclass-specific Fc N-glycomes and T2DM was observed in the Uyghur population sample in China, suggesting a potential for the IgG Fc glycosylation as a biomarker candidate for type 2 diabetes. The integration of glycomics with other system science biomarkers might offer further hope for innovation in diagnosis and treatment of T2DM in the future. Finally, it is noteworthy that “Population Glycomics” is an emerging approach to biomarker discovery for common complex diseases.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
EK-H2020-722095 - Exploitation of Glycosylation Signatures for Precision Medicine (GlySign) (EK - H2020-MSCA-ITN-2016) ( CroRIS)
EK-H2020-676421 - Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics (GlyCoCan) (,, EK - H2020-MSCA-ITN-2015) ( CroRIS)
EK-H2020-733100 - A Systems medicine approach to chronic inflammatory disease (SYSCID) (Zoldoš, Vlatka; Lauc, Gordan, EK - H2020-SC1-2016-RTD) ( CroRIS)
EK-H2020-721815 - Innovative training in methods for future data (IMforFUTURE) (Zoldoš, Vlatka; Lauc, Gordan, EK - H2020-MSCA-ITN-2016) ( CroRIS)
EK-EFRR-KK.01.2.1.01.0003 - Nova generacija visokoprotočnih glikoservisa (Lauc, Gordan; Gornik Kljaić, Olga; Zoldoš, Vlatka, EK - Poziv na dostavu projektnih prijedloga „Povećanje razvoja novih proizvoda i usluga koji proizlaze iz aktivnosti istraživanja i razvoja“) ( CroRIS)
EK-KF-KK.01.1.1.01.0010 - Znanstveni centar izvrsnosti za personaliziranu brigu o zdravlju (ZCIPersonHealth) (Polašek, Ozren; Secenji, Aleksandar, EK ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Liu, Jiaonan; Dolikun, Mamatyusupu; Štambuk, Jerko; Trbojević-Akmačić, Irena; Zhang, Jie; Zhang, Jinxia; Wang, Hao; Meng, Xiaoni; Razdorov, Genadij; Menon, Desmond et al.
Glycomics for type 2 diabetes biomarker discovery: promise of immunoglobulin G subclass-specific fragment crystallizable N-glycosylation in the Uyghur population // Omics-a journal of integrative biology, 23 (2019), 12; 640-648 doi:10.1089/omi.2019.0052 (međunarodna recenzija, članak, znanstveni)
Liu, J., Dolikun, M., Štambuk, J., Trbojević-Akmačić, I., Zhang, J., Zhang, J., Wang, H., Meng, X., Razdorov, G. & Menon, D. (2019) Glycomics for type 2 diabetes biomarker discovery: promise of immunoglobulin G subclass-specific fragment crystallizable N-glycosylation in the Uyghur population. Omics-a journal of integrative biology, 23 (12), 640-648 doi:10.1089/omi.2019.0052.
@article{article, author = {Liu, Jiaonan and Dolikun, Mamatyusupu and \v{S}tambuk, Jerko and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Zhang, Jie and Zhang, Jinxia and Wang, Hao and Meng, Xiaoni and Razdorov, Genadij and Menon, Desmond and Zheng, Deqiang and Wu, Lijuan and Wang, Youxin and Song, Manshu and Lauc, Gordan and Wang, Wei}, year = {2019}, pages = {640-648}, DOI = {10.1089/omi.2019.0052}, keywords = {type 2 diabetes mellitus, glycomics, biomarkers, personalized medicine, IgG, subclass-specific Fc glycosylation, Uyghur population}, journal = {Omics-a journal of integrative biology}, doi = {10.1089/omi.2019.0052}, volume = {23}, number = {12}, issn = {1536-2310}, title = {Glycomics for type 2 diabetes biomarker discovery: promise of immunoglobulin G subclass-specific fragment crystallizable N-glycosylation in the Uyghur population}, keyword = {type 2 diabetes mellitus, glycomics, biomarkers, personalized medicine, IgG, subclass-specific Fc glycosylation, Uyghur population} }
@article{article, author = {Liu, Jiaonan and Dolikun, Mamatyusupu and \v{S}tambuk, Jerko and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Zhang, Jie and Zhang, Jinxia and Wang, Hao and Meng, Xiaoni and Razdorov, Genadij and Menon, Desmond and Zheng, Deqiang and Wu, Lijuan and Wang, Youxin and Song, Manshu and Lauc, Gordan and Wang, Wei}, year = {2019}, pages = {640-648}, DOI = {10.1089/omi.2019.0052}, keywords = {type 2 diabetes mellitus, glycomics, biomarkers, personalized medicine, IgG, subclass-specific Fc glycosylation, Uyghur population}, journal = {Omics-a journal of integrative biology}, doi = {10.1089/omi.2019.0052}, volume = {23}, number = {12}, issn = {1536-2310}, title = {Glycomics for type 2 diabetes biomarker discovery: promise of immunoglobulin G subclass-specific fragment crystallizable N-glycosylation in the Uyghur population}, keyword = {type 2 diabetes mellitus, glycomics, biomarkers, personalized medicine, IgG, subclass-specific Fc glycosylation, Uyghur population} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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