Naslov
N-glycosylation profiling of Type 2 diabetes mellitus from baseline to follow-up: an observational study in a Ghanaian population
(N-glycosylation profiling of Type 2 diabetes mellitus from baseline to follow-up: an observational study in a Ghanaian population)

Autori
Adua, Eric ; Memarian, Elham ; Afrifa-Yamoah, Ebenezer ; Russell, Alyce ; Trbojević-Akmačić, Irena ; Gudelj, Ivan ; Jurić, Julija ; Roberts, Peter ; Lauc, Gordan ; Wang, Wei

Izvornik
Biomarkers in medicine (1752-0363) 15 (2021), 7; 467-480

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
biomarker ; N-glycans ; stability ; Type 2 diabetes mellitus ; ultra-performance liquid chromatography

Sažetak
Aim: The study sought to determine the patterns of N-glycan profiles among Type 2 diabetes mellitus (T2DM) patients over a 6-month period. Materials & methods: Biochemical and clinical data were obtained from 253 T2DM patients at baseline and follow-up. Ultra-performance liquid chromatography and statistical methods were applied for N-glycan profiling. Results: The coefficients of variation were 28% and 29% at baseline and follow-up, respectively, whereas the range of N-glycan variability was from 11% to 56%. Apart from GP1 (FA2) and GP29 (FA3G3S [3, 3, 3]3), the intra- individual variations of N-glycan peaks were not statistically significant. Conclusion: N-glycan profiles were stable over 6-month period in T2DM patients and could be used to monitor biochemical changes in relation with T2DM comorbidities.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA