Naslov
Yeast extract demonstrates rapid itch relief in chronic pruritus

Autori
Zhang, Y. ; Tan, Y. ; Zou, Y. ; Bulat V. ; Lugovic Mihic, L ; Kovacevic, M. ; Lotti, T. ; Verner, I. ; Stanimirovic, A. ; Šitum, M. ; Goldust, M. ; Liu, W. ; Vojvodic, A. ; Goren. A.

Izvornik
Journal of cosmetic dermatology (1473-2130) 19 (2020), 8; 2131-2134

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic ; pruritis ; yeast.

Sažetak
Background: Pruritus is the most common complaint encountered in dermatological practice. It is estimated that up to 4% of the world population suffers from chronic itch. Chronic pruritus can be associated with both cutaneous or systemic conditions. While a plethora of treatments attempt to address itch, most carry risk of significant adverse events with chronic use ; thus, there exists an unmet need to develop safe treatments for chronic pruritus. A recent study demonstrated that a novel extract from Saccharomyces cerevisiae, that is, Baker's yeast, blocks various histamine receptors as well as inhibits numerous inflammatory cytokines. Methods: Given the long- term safety profile of Baker's yeast, we set to investigate the efficacy of the novel extract in the treatment of chronic pruritus. Key results: In our study, we demonstrated that within 30 minutes, the novel extract significantly reduced itch when compared to a placebo lotion (P = .0020). Conclusions: To our knowledge, this is the first study demonstrating that a novel extract from Saccharomyces cerevisiae can provide rapid and sustained itch relief to chronic pruritus patients.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA