Pregled bibliografske jedinice broj: 1135578
Salivary cortisol response to psychosocial stress in patients with first-episode psychosis
Salivary cortisol response to psychosocial stress in patients with first-episode psychosis // Croatian medical journal, 62 (2021), 1; 80-89 doi:10.3325/cmj.2021.62.80 (međunarodna recenzija, članak, znanstveni)
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Naslov
Salivary cortisol response to psychosocial stress in
patients with first-episode psychosis
Autori
Rossini Gajšak, Linda ; Vogrinc, Željka ; Čelić Ružić, Mirela ; Bošnjak Kuharić, Dina ; Bošković, Marija ; Koričančić Makar, Ana ; Makarić, Porin ; Ermakora, Vesna ; Kekin, Ivana ; Bajić, Žarko ; Rojnić Kuzman, Martina
Izvornik
Croatian medical journal (0353-9504) 62
(2021), 1;
80-89
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
salivary cortisol ; first episode psychosis ; schizophrenia ; psychosocial stress
Sažetak
Aim: To analyze the difference in the salivary cortisol response to psychosocial stress between the patients with the first episode of psychosis (FEP) and the control group. Methods: We performed a cross-sectional analysis of the baseline measurements of a prospective cohort study conducted from 2015 to 2018 at two Croatian psychiatric hospitals. The study consecutively enrolled 53 patients diagnosed with FEP and 63 healthy controls. The primary outcome was the difference in the changes of salivary cortisol concentration during the stress test. The secondary outcome was the difference in the baseline levels of salivary cortisol between patients with FEP and controls. The tertiary outcome were the correlations of salivary cortisol levels with the results of the Positive and Negative Syndrome Scale for Schizophrenia, Rosenberg Self-Esteem Scale, and the International Personality Item Pool. Results: Patients with FEP had significantly higher baseline salivary cortisol than controls, but their salivary cortisol increased significantly less during the stress test. Conclusion: Patients with FEP respond differently to stressful stimuli than controls, as shown by the increased baseline salivary cortisol and blunted cortisol response, possibly indicating a greater vulnerability to psychosocial stress.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
--UIP-2014-09-1245 - Biomarkeri u shizofreniji – integracija komplementarnih prisutupa u praćenju osoba s prvom psihotičnom epizodom (BIS – LF FEP) (Rojnić Kuzman, Martina) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb,
Psihijatrijska bolnica "Sveti Ivan" Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE