Pregled bibliografske jedinice broj: 1135577
General Functioning in Patients With First-Episode Psychosis After the First 18 Months of Treatment
General Functioning in Patients With First-Episode Psychosis After the First 18 Months of Treatment // Journal of clinical psychopharmacology, 40 (2020), 4; 366-372 doi:10.1097/JCP.0000000000001224 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1135577 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
General Functioning in Patients With First-Episode
Psychosis After the First 18 Months of Treatment
Autori
Rojnic Kuzman, Martina ; Makaric, Porin ; Bosnjak Kuharic, Dina ; Kekin, Ivana ; Madzarac, Zoran ; Koricancic Makar, Ana ; Bajic, Zarko ; Ostojic, Drazenka ; Silic, Ante ; Zivkovic, Maja
Izvornik
Journal of clinical psychopharmacology (0271-0749) 40
(2020), 4;
366-372
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Schizophrenia ; first-episode psychosis ; treatment ; functioning ; neurocognitive symptoms
Sažetak
Background: One of the main goals in the treatment of first-episode psychosis (FEP) is achieving functional remission. This study aims to analyze whether initial neurocognitive status and the use of specific pharmacological and psychosocial treatment options in FEP can predict general functioning after 18 months of treatment. Methods: We conducted a longitudinal naturalistic study with a sample of 129 patients with FEP treated at 2 Croatian psychiatric clinics from 2016until 2018. Ordinal regression was used to predict the global level of functioning assessed with the Global Assessment of Functioning scale (GAF) at the 18th month of treatment from the baseline symptoms (assessed with a set of neurocognitive tests) and different treatment options. Results: Higher score on GAF at the 18th month was significantly predicted by female sex, better baseline verbal memory and GAF scores, and the type of treatment. Group multimodal psychosocial treatment, antipsychotic polytherapy, and not being treated with sedatives at baseline predicted better GAF scores at follow-up. In the exploratory analysis, taking sedatives in the final assessment and being rehospitalized due to relapse predicted worse GAF scores at the end of follow-up. Conclusions: Although baseline neurocognitive features and baseline general functioning seem to influence the overall long-term functioning of persons with FEP, addition of a multimodal group psychosocial treatment program and appropriate medication seem to be equally important for improving the patients' level of functioning after the FEP.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)
POVEZANOST RADA
Projekti:
--UIP-2014-09-1245 - Biomarkeri u shizofreniji – integracija komplementarnih prisutupa u praćenju osoba s prvom psihotičnom epizodom (BIS – LF FEP) (Rojnić Kuzman, Martina) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb
Profili:
Draženka Ostojić
(autor)
Maja Živković
(autor)
Martina Rojnić Kuzman
(autor)
Ante Silić
(autor)
Zoran Madžarac
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE