Naslov
EFFECT OF AGARICUS BISPORUS ON KINETICS OF MEMORY T CELLS FROM LAMB PERIPHERAL BLOOD

Autori
Pajurin, Luka ; Špoljarić , Daniel ; Vlahović , Ksenija ; Špoljarić , Branimira ; Vince , Silvijo ; Miliković-Tur , Suzana ; Poljičak- Milas , Nina ; Cvrtila , Željka ; Mikuš , Tomislav ; Hrković-Porobija , Amina ; Popović , Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Veterinaria / - , 2021, 279-279

Skup
12th days BHAAAS, International Symposium of Veterinary Medicine and Forestry

Mjesto i datum
Mostar, Bosna i Hercegovina, 24.06.2021. - 27.06.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Agaricus bisporus, immunomodulation, lamb, Lika pramenka breed, memory T cells

Sažetak
In the available literature, the immunostimulatory effect of the button mushroom (Agaricus bisporus) dietary supplement mixed in the daily rations has been described in monogastric animals kept in controlled environment and intensive production conditions. Thus, after 42 days of feeding with the Agaricus bisporus dietary supplement, an increase in the proportion of T and B lymphocytes was recorded in the peripheral blood of domestic pigs and broilers. The aim of the research was to determine the effect of Agaricus bisporus on the kinetics and change in the proportion of memory T cells in lambs. Thirty lambs of the Lika pramenka breed at the age of three months were used in the experiment. The lambs were divided into two groups: control (without addition of Agaricus bisporus supplement in daily rations) and experimental (with addition of 1.5% dry Agaricus bisporus supplement in daily rations). On days 0 and 42 of the experiment, cytometric analysis of lamb peripheral blood lymphocytes was performed using directly fluorochrome- labeled specific mouse monoclonal antibodies for memory T cells of sheep (antibody panel: CD45+ CD3+ CD8+ CD4+). Statistical data analysis was performed using the SAS 9.4. software package. On the 42nd day of the experiment, in lambs fed with the addition of 1.5% dry Agaricus bisporus supplement in daily rations, a 0.33% higher share of memory T cells was recorded compared to control group lambs. There is a general lack of scientific information about the immunomodulatory effect of Agaricus bisporus in ruminants. Therefore, the results obtained in this paper are scientific recommendations for further assessment of T cells kinetics, as well as other subpopulations, during and after feeding with Agaricus bisporus dietary supplement. This study has been fully supported by the Croatian Science Foundation under the project “Innovative functional lamb meat products” (HRZZ-IP-06-2016-3685).

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA