Pregled bibliografske jedinice broj: 1133700
Effects of estradiol on biological age measured using the glycan age index
Effects of estradiol on biological age measured using the glycan age index // Aging-US, 12 (2020), 19; 19756-19765 doi:10.18632/aging.104060 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1133700 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Effects of estradiol on biological age measured
using the glycan age index
Autori
Jurić, Julija ; Kohrt, Wendy M. ; Kifer, Domagoj ; Gavin, Kathleen M ; Pezer, Marija ; Nigrovic, Peter A. ; Lauc, Gordan
Izvornik
Aging-US (1945-4589) 12
(2020), 19;
19756-19765
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
aging biomarkers ; biological age ; estrogen ; glycan age ; glycosylation
Sažetak
Glycan age is a recently developed biomarker based on glycans attached to immunoglobulin G (IgG). In large population cohorts, glycan age associates well with lifestyle and disease-risk biomarkers, while some studies suggested that glycan changes precede development of several age-associated diseases. In this study we evaluated effects of estrogen on the glycan age. Gonadal hormones were suppressed in 36 healthy young women by gonadotropin releasing hormone agonist therapy for 6 months. In 15 of them estradiol was supplemented, while 21 received placebo resulting in very low estrogen levels during intervention. IgG was isolated from plasma samples before intervention, after 6 months of intervention and after subsequent 4- month recovery. Deprivation of gonadal hormones resulted in median increase of glycan age for 9.1 years (IQR 6.8 – 11.5 years, p = 3.73×10-8), which was completely prevented by transdermal estradiol therapy (change in glycan age = -0.23 years, IQR (-2.20 – 2.98). After the recovery period glycan age returned to baseline values in both groups. These results suggest that IgG glycans and consequently also the glycan age are under strong influence of gonadal hormones and that estradiol therapy can prevent the increase of glycan age that occurs in the perimenopausal period.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
EK-EFRR-KK.01.2.2.03.0006 - Centar kompetencija u molekularnoj dijagnostici (CEKOM) (Knjaz, Damir; Lauc, Gordan; Vugrek, Oliver; Polašek, Ozren, EK - KK.01.2.2.03) ( CroRIS)
EK-EFRR-KK.01.2.1.01.0003 - Nova generacija visokoprotočnih glikoservisa (Lauc, Gordan; Gornik Kljaić, Olga; Zoldoš, Vlatka, EK - Poziv na dostavu projektnih prijedloga „Povećanje razvoja novih proizvoda i usluga koji proizlaze iz aktivnosti istraživanja i razvoja“) ( CroRIS)
EK-KF-KK.01.1.1.01.0010 - Znanstveni centar izvrsnosti za personaliziranu brigu o zdravlju (ZCIPersonHealth) (Polašek, Ozren; Secenji, Aleksandar, EK ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.
Poveznice na cjeloviti tekst rada:
Pristup cjelovitom tekstu rada doi www.aging-us.com www.ncbi.nlm.nih.govCitiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE