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Pregled bibliografske jedinice broj: 1133533

A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies

Nižić Nodilo, Laura; Ugrina, Ivo; Špoljarić, Drago; Amidžić Klarić, Daniela; Jakobušić Brala, Cvijeta; Perkušić, Mirna; Pepić, Ivan; Lovrić, Jasmina; Saršon, Vesna; Safundžić Kučuk, Maša et al.
A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies // Pharmaceutics, 13 (2021), 6; 795, 30 doi:10.3390/pharmaceutics13060795 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1133533 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies

Autori
Nižić Nodilo, Laura ; Ugrina, Ivo ; Špoljarić, Drago ; Amidžić Klarić, Daniela ; Jakobušić Brala, Cvijeta ; Perkušić, Mirna ; Pepić, Ivan ; Lovrić, Jasmina ; Saršon, Vesna ; Safundžić Kučuk, Maša ; Zadravec, Dijana ; Kalogjera, Livije ; Hafner, Anita

Izvornik
Pharmaceutics (1999-4923) 13 (2021), 6; 795, 30

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dexamethasone sodium phosphate ; nose-to-brain delivery ; spray-dried microspheres ; pectin ; hypromellose ; mannitol ; 3D nasal cavity model ; in vitro nasal deposition

Sažetak
Nasal route of administration offers a unique opportunity of brain targeted drug delivery via olfactory and trigeminal pathway, providing effective CNS concentrations at lower doses and lower risk for adverse reactions compared to systemic drug administration. Therefore, it has been recently proposed as a route of choice for glucocorticoids to control neuroinflammation processes in patients with severe Covid-19. However, appropriate delivery systems tailored to enhance their efficacy yet need to emerge. In this work we present the development of sprayable brain targeting powder delivery platform of dexamethasone sodium phosphate (DSP). DSP-loaded microspheres, optimised employing Quality-by- Design approach, were blended with soluble inert carriers (mannitol or lactose monohydrate). Powder blends were characterized in terms of homogeneity, flow properties, sprayability, in vitro biocompatibility, permeability and mucoadhesion. Nasal deposition studies were performed using 3D printed nasal cavity model. Mannitol provided better powder blend flow properties compared to lactose. Microspheres blended with mannitol retained or enlarged their mucoadhesive properties and enhanced DSP permeability across epithelial model barrier. DSP dose fraction deposited in the olfactory region reached 17.0% revealing the potential of developed powder platform for targeted olfactory delivery. The observed impact of nasal cavity asymmetry highlighted the importance of individual approach when aiming olfactory region.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA

Projekti:
HRZZ-UIP-2017-05-4592 - Optimiranje depozicije raspršenih in situ gelirajućih i praškastih terapijskih sustava u nosnoj šupljini (OptiNasalSpray) (Hafner, Anita, HRZZ - 2017-05) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Stomatološki fakultet, Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Prirodoslovno-matematički fakultet, Split

Profili:

Avatar Url Dijana Zadravec (autor)

Avatar Url Anita Hafner (autor)

Avatar Url Livije Kalogjera (autor)

Avatar Url Ivan Pepić (autor)

Avatar Url Daniela Amidžić Klarić (autor)

Avatar Url Laura Nižić Nodilo (autor)

Avatar Url Mirna Perkušić (autor)

Avatar Url Ivo Ugrina (autor)

Avatar Url Maša Safundžić Kučuk (autor)

Avatar Url Jasmina Lovrić (autor)

Avatar Url Drago Špoljarić (autor)

Avatar Url Cvijeta Jakobušić Brala (autor)

Poveznice na cjeloviti tekst rada:

doi pdfs.semanticscholar.org doi.org

Citiraj ovu publikaciju:

Nižić Nodilo, Laura; Ugrina, Ivo; Špoljarić, Drago; Amidžić Klarić, Daniela; Jakobušić Brala, Cvijeta; Perkušić, Mirna; Pepić, Ivan; Lovrić, Jasmina; Saršon, Vesna; Safundžić Kučuk, Maša et al.
A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies // Pharmaceutics, 13 (2021), 6; 795, 30 doi:10.3390/pharmaceutics13060795 (međunarodna recenzija, članak, znanstveni)
Nižić Nodilo, L., Ugrina, I., Špoljarić, D., Amidžić Klarić, D., Jakobušić Brala, C., Perkušić, M., Pepić, I., Lovrić, J., Saršon, V. & Safundžić Kučuk, M. (2021) A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies. Pharmaceutics, 13 (6), 795, 30 doi:10.3390/pharmaceutics13060795.
@article{article, author = {Ni\v{z}i\'{c} Nodilo, Laura and Ugrina, Ivo and \v{S}poljari\'{c}, Drago and Amid\v{z}i\'{c} Klari\'{c}, Daniela and Jakobu\v{s}i\'{c} Brala, Cvijeta and Perku\v{s}i\'{c}, Mirna and Pepi\'{c}, Ivan and Lovri\'{c}, Jasmina and Sar\v{s}on, Vesna and Safund\v{z}i\'{c} Ku\v{c}uk, Ma\v{s}a and Zadravec, Dijana and Kalogjera, Livije and Hafner, Anita}, year = {2021}, pages = {30}, DOI = {10.3390/pharmaceutics13060795}, chapter = {795}, keywords = {dexamethasone sodium phosphate, nose-to-brain delivery, spray-dried microspheres, pectin, hypromellose, mannitol, 3D nasal cavity model, in vitro nasal deposition}, journal = {Pharmaceutics}, doi = {10.3390/pharmaceutics13060795}, volume = {13}, number = {6}, issn = {1999-4923}, title = {A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies}, keyword = {dexamethasone sodium phosphate, nose-to-brain delivery, spray-dried microspheres, pectin, hypromellose, mannitol, 3D nasal cavity model, in vitro nasal deposition}, chapternumber = {795} }
@article{article, author = {Ni\v{z}i\'{c} Nodilo, Laura and Ugrina, Ivo and \v{S}poljari\'{c}, Drago and Amid\v{z}i\'{c} Klari\'{c}, Daniela and Jakobu\v{s}i\'{c} Brala, Cvijeta and Perku\v{s}i\'{c}, Mirna and Pepi\'{c}, Ivan and Lovri\'{c}, Jasmina and Sar\v{s}on, Vesna and Safund\v{z}i\'{c} Ku\v{c}uk, Ma\v{s}a and Zadravec, Dijana and Kalogjera, Livije and Hafner, Anita}, year = {2021}, pages = {30}, DOI = {10.3390/pharmaceutics13060795}, chapter = {795}, keywords = {dexamethasone sodium phosphate, nose-to-brain delivery, spray-dried microspheres, pectin, hypromellose, mannitol, 3D nasal cavity model, in vitro nasal deposition}, journal = {Pharmaceutics}, doi = {10.3390/pharmaceutics13060795}, volume = {13}, number = {6}, issn = {1999-4923}, title = {A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies}, keyword = {dexamethasone sodium phosphate, nose-to-brain delivery, spray-dried microspheres, pectin, hypromellose, mannitol, 3D nasal cavity model, in vitro nasal deposition}, chapternumber = {795} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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