Naslov
Bis(triazolylpyrene)-derived Pseudopeptides as Potential Fluorescent Sensors: Application in Cell Imaging

Autori
Belovari, Mateja ; Nestić, Davor ; Majhen, Dragomira ; Džolić, Zoran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka - 5. Simpozij doktorskih studenata PMF-a / Barišić, Dajana - Zagreb, 2021, 310--

Skup
5. Simpozij studenata doktorskih studija PMF-a = 5th Faculty of Science PhD Student Symposium

Mjesto i datum
Zagreb, Hrvatska, 24.04.2021. - 25.04.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Pyrene, Self-assembly, Self-aggregation, Nanoaggregates in Cells, Confocal Fluorescence Microscopy

Sažetak
Fluorescence imaging is emerging as promising and powerful means for monitoring various bioactive molecules in living systems, which is thanks to its remarkable advantages, such as easy operation, high sensitivity and high temporal- spatial resolution [1]. In recent years, many fluorescent probes for various bioactive molecules have been reported, which has facilitated advances in cell biology and therapeutic imaging [2]. Polyaromatic chromophores are one of the most researched groups of fluorophores due to their different emission properties. Pyrene derivatives are intensively used as signal units in structural studies of biomolecules and molecule sensing, due to their properties [3]. Pyrene is an efficient chromophore with excellent fluorescent quantum yield, high detection sensitivity and efficient excimer emission that makes it useful as a fluorescence sensor. To regulate the fluorescence behaviors of pyrene-derived fluorophores, the assistance of self-complementary groups has been proved to be an efficient way to modulate the aggregating states of pyrene-related fluorophores [4]. With purpose of developing the new chemosensor molecules , we report on the design and synthesis of novel bis(triazolylpyrene)-derived pseudopeptide fluorophores, their photophysical and self-aggregation properties, as well as confocal fluorescence microscopy studies.

Izvorni jezik
Engleski

POVEZANOST RADA