Naslov
Neuroplastin in human cognition: review of literature and future perspectives
(Neuroplastin in human cognition: review of literature and future perspectives)

Autori
Ilić, Katarina ; Mlinac Jerković, Kristina ; Sedmak, Goran ; Rosenzweig, Ivana ; Kalanj Bognar, Svjetlana

Izvornik
Translational Psychiatry (2158-3188) 11 (2021); 394, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
neurodegeneration ; synaptic plasticity ; neuronal calcium homeostasis

Sažetak
Synaptic glycoprotein neuroplastin is involved in synaptic plasticity and complex molecular events underlying learning and memory. Studies in mice and rats suggest that neuroplastin is essential for cognition, as it is needed for long-term potentiation and associative memory formation. Recently, it was found that some of effects of neuroplastin are related to regulation of calcium homeostasis through interactions with plasma membrane calcium ATPases. Neuroplastin is increasingly seen as a key player in complex brain functions, but studies in humans remain scarce. Here, we summarize present knowledge about neuroplastin in human tissues and argue its genetic association with cortical thickness, intelligence, schizophrenia and autism ; specific immunolocalization depicting hippocampal trisynaptic pathway ; potential role in tissue compensatory response in neurodegeneration ; high, almost housekeeping, level of spatio-temporal gene expression in human brain. We also propose that neuroplastin acts as a housekeeper of neuroplasticity, and that it may be considered as an important novel cognition-related molecule in humans. Several promising directions for future investigations are suggested which may complete our understanding of neuroplastin actions in molecular basis of human cognition.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA