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Pregled bibliografske jedinice broj: 1132371

Antiviral cytokine response in neuroinvasive and non-neuroinvasive West Nile virus infection


Židovec-Lepej, Snježana; Vilibić-Čavlek, Tatjana; Barbić, Ljubo; Ilić, Maja; Savić, Vladimir; Tabain, Irena; Ferenc, Thomas; Grgić, Ivana; Gorenec, Lana; Bogdanić, Maja et al.
Antiviral cytokine response in neuroinvasive and non-neuroinvasive West Nile virus infection // Viruses, 13 (2021), 2; 342, 12 doi:10.3390/v13020342 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1132371 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Antiviral cytokine response in neuroinvasive and non-neuroinvasive West Nile virus infection

Autori
Židovec-Lepej, Snježana ; Vilibić-Čavlek, Tatjana ; Barbić, Ljubo ; Ilić, Maja ; Savić, Vladimir ; Tabain, Irena ; Ferenc, Thomas ; Grgić, Ivana ; Gorenec, Lana ; Bogdanić, Maja ; Stevanović, Vladimir ; Sabadi, Dario ; Perić, Ljiljana ; Potočnik-Hunjadi, Tanja ; Dvorski, Elizabeta ; Butigan, Tamara ; Capak, Krunoslav ; Listes, Eddy ; Savini, Giovanni

Izvornik
Viruses (1999-4915) 13 (2021), 2; 342, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
West Nile virus ; immune response ; neuro-invasive disease ; West Nile fever

Sažetak
Data on the immune response to West Nile virus (WNV) are limited. We analyzed the antiviral cytokine response in serum and cerebrospinal fluid (CSF) samples of patients with WNV fever and neuroinvasive disease using a multiplex bead- based assay for the simultaneous quantification of13 human cytokines. The panel included cytokines associated with innate and early pro- inflammatory immune responses (TNF- α/IL-6), Th1 (IL-2/IFN-γ), Th2 (IL-4/IL-5/IL- 9/IL-13), Th17 immune response(IL-17A/IL- 17F/IL-21/IL-22) and the key anti-inflammatory cytokine IL-10. Elevated levels of IFN-γwere detected in 71.7% of CSF and 22.7% of serum samples (p= 0.003). Expression of IL-2/IL- 4/TNF-αand Th1 17 cytokines (IL-17A/IL-17F/IL- 21) was detected in the serum but not in the CSF (except one positive CSF sample for IL- 17F/IL-4). While IL-6 levels were markedly higher in the CSF compared to serum (CSF median 2036.71, IQR 213.82– 6190.50 ; serum median 24.48, IQR 11.93–49.81 ; p< 0.001), no difference in the IL-13/IL-9/IL-10/IFN- γ/IL-22 levels in serum/CSF was found. In conclusion, increased concentrations of the key cytokines associated with innate and early acute phase responses(IL-6) and Th1 type immune responses (IFN-γ) were found in the CNS of patients with WNV infection. In contrast, expression of the key T-cell growth factor IL-2, Th17 cytokines, a Th2 cytokine IL-4 and the proinflammatory cytokine TNF-αappear to be concentrated mainly in the periphery.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-7456 - Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske (CRONEUROARBO) (Vilibić Čavlek, Tatjana, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Hrvatski zavod za javno zdravstvo,
Klinička bolnica "Merkur",
Hrvatski veterinarski institut, Zagreb,
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Opća bolnica Varaždin,
Medicinski fakultet, Osijek

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Židovec-Lepej, Snježana; Vilibić-Čavlek, Tatjana; Barbić, Ljubo; Ilić, Maja; Savić, Vladimir; Tabain, Irena; Ferenc, Thomas; Grgić, Ivana; Gorenec, Lana; Bogdanić, Maja et al.
Antiviral cytokine response in neuroinvasive and non-neuroinvasive West Nile virus infection // Viruses, 13 (2021), 2; 342, 12 doi:10.3390/v13020342 (međunarodna recenzija, članak, znanstveni)
Židovec-Lepej, S., Vilibić-Čavlek, T., Barbić, L., Ilić, M., Savić, V., Tabain, I., Ferenc, T., Grgić, I., Gorenec, L. & Bogdanić, M. (2021) Antiviral cytokine response in neuroinvasive and non-neuroinvasive West Nile virus infection. Viruses, 13 (2), 342, 12 doi:10.3390/v13020342.
@article{article, author = {\v{Z}idovec-Lepej, Snje\v{z}ana and Vilibi\'{c}-\v{C}avlek, Tatjana and Barbi\'{c}, Ljubo and Ili\'{c}, Maja and Savi\'{c}, Vladimir and Tabain, Irena and Ferenc, Thomas and Grgi\'{c}, Ivana and Gorenec, Lana and Bogdani\'{c}, Maja and Stevanovi\'{c}, Vladimir and Sabadi, Dario and Peri\'{c}, Ljiljana and Poto\v{c}nik-Hunjadi, Tanja and Dvorski, Elizabeta and Butigan, Tamara and Capak, Krunoslav and Listes, Eddy and Savini, Giovanni}, year = {2021}, pages = {12}, DOI = {10.3390/v13020342}, chapter = {342}, keywords = {West Nile virus, immune response, neuro-invasive disease, West Nile fever}, journal = {Viruses}, doi = {10.3390/v13020342}, volume = {13}, number = {2}, issn = {1999-4915}, title = {Antiviral cytokine response in neuroinvasive and non-neuroinvasive West Nile virus infection}, keyword = {West Nile virus, immune response, neuro-invasive disease, West Nile fever}, chapternumber = {342} }
@article{article, author = {\v{Z}idovec-Lepej, Snje\v{z}ana and Vilibi\'{c}-\v{C}avlek, Tatjana and Barbi\'{c}, Ljubo and Ili\'{c}, Maja and Savi\'{c}, Vladimir and Tabain, Irena and Ferenc, Thomas and Grgi\'{c}, Ivana and Gorenec, Lana and Bogdani\'{c}, Maja and Stevanovi\'{c}, Vladimir and Sabadi, Dario and Peri\'{c}, Ljiljana and Poto\v{c}nik-Hunjadi, Tanja and Dvorski, Elizabeta and Butigan, Tamara and Capak, Krunoslav and Listes, Eddy and Savini, Giovanni}, year = {2021}, pages = {12}, DOI = {10.3390/v13020342}, chapter = {342}, keywords = {West Nile virus, immune response, neuro-invasive disease, West Nile fever}, journal = {Viruses}, doi = {10.3390/v13020342}, volume = {13}, number = {2}, issn = {1999-4915}, title = {Antiviral cytokine response in neuroinvasive and non-neuroinvasive West Nile virus infection}, keyword = {West Nile virus, immune response, neuro-invasive disease, West Nile fever}, chapternumber = {342} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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