Pregled bibliografske jedinice broj: 1132371
Antiviral cytokine response in neuroinvasive and non-neuroinvasive West Nile virus infection
Antiviral cytokine response in neuroinvasive and non-neuroinvasive West Nile virus infection // Viruses, 13 (2021), 2; 342, 12 doi:10.3390/v13020342 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1132371 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Antiviral cytokine response in neuroinvasive and
non-neuroinvasive West Nile virus infection
Autori
Židovec-Lepej, Snježana ; Vilibić-Čavlek, Tatjana ; Barbić, Ljubo ; Ilić, Maja ; Savić, Vladimir ; Tabain, Irena ; Ferenc, Thomas ; Grgić, Ivana ; Gorenec, Lana ; Bogdanić, Maja ; Stevanović, Vladimir ; Sabadi, Dario ; Perić, Ljiljana ; Potočnik-Hunjadi, Tanja ; Dvorski, Elizabeta ; Butigan, Tamara ; Capak, Krunoslav ; Listes, Eddy ; Savini, Giovanni
Izvornik
Viruses (1999-4915) 13
(2021), 2;
342, 12
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
West Nile virus ; immune response ; neuro-invasive disease ; West Nile fever
Sažetak
Data on the immune response to West Nile virus (WNV) are limited. We analyzed the antiviral cytokine response in serum and cerebrospinal fluid (CSF) samples of patients with WNV fever and neuroinvasive disease using a multiplex bead- based assay for the simultaneous quantification of13 human cytokines. The panel included cytokines associated with innate and early pro- inflammatory immune responses (TNF- α/IL-6), Th1 (IL-2/IFN-γ), Th2 (IL-4/IL-5/IL- 9/IL-13), Th17 immune response(IL-17A/IL- 17F/IL-21/IL-22) and the key anti-inflammatory cytokine IL-10. Elevated levels of IFN-γwere detected in 71.7% of CSF and 22.7% of serum samples (p= 0.003). Expression of IL-2/IL- 4/TNF-αand Th1 17 cytokines (IL-17A/IL-17F/IL- 21) was detected in the serum but not in the CSF (except one positive CSF sample for IL- 17F/IL-4). While IL-6 levels were markedly higher in the CSF compared to serum (CSF median 2036.71, IQR 213.82– 6190.50 ; serum median 24.48, IQR 11.93–49.81 ; p< 0.001), no difference in the IL-13/IL-9/IL-10/IFN- γ/IL-22 levels in serum/CSF was found. In conclusion, increased concentrations of the key cytokines associated with innate and early acute phase responses(IL-6) and Th1 type immune responses (IFN-γ) were found in the CNS of patients with WNV infection. In contrast, expression of the key T-cell growth factor IL-2, Th17 cytokines, a Th2 cytokine IL-4 and the proinflammatory cytokine TNF-αappear to be concentrated mainly in the periphery.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-7456 - Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske (CRONEUROARBO) (Vilibić Čavlek, Tatjana, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Hrvatski zavod za javno zdravstvo,
Klinička bolnica "Merkur",
Hrvatski veterinarski institut, Zagreb,
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Opća bolnica Varaždin,
Medicinski fakultet, Osijek
Profili:
Vladimir Stevanović
(autor)
Thomas Ferenc
(autor)
Ljiljana Perić
(autor)
Dario Sabadi
(autor)
Maja Bogdanić
(autor)
Irena Tabain
(autor)
Lana Gorenec
(autor)
Krunoslav Capak
(autor)
Maja Ilić Tomaš
(autor)
Tatjana Vilibić-Čavlek
(autor)
Ljubo Barbić
(autor)
Vladimir Savić
(autor)
Ivana Grgić
(autor)
Snježana Židovec-Lepej
(autor)
Eddy Listeš
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE