Naslov
“One pot” pristup sintezi monodentatnih oksazolina s aromatskom jezgrom - asimetrična supstitucija prekursora u jednom koraku
("One pot" approach to synthesizing monodentate oxazolines with an aromatic core – Asymmetric substitution of precursors in one step)

Autori
Bakija, Marija ; Kirin, Srećko, I.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Simpozij studenata doktorskih studija PMF-a : knjiga sažetaka = PhD Student Symposium 2021 : book of abstracts / Barišić, Dajana - : Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2021, 308-309

ISBN
978-953-6076-90-1

Skup
5. Simpozij studenata doktorskih studija PMF-a = 5th Faculty of Science PhD Student Symposium

Mjesto i datum
Zagreb, Hrvatska, 24.04.2021. - 25.04.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
monodentatnih oksazolini ; kataliza
(oxazoline ; catalysis ; monodentate)

Sažetak
The application of oxazoline ligands in asymmetric catalysis is successfully carried out in many important reactions with very high enantioselectivities [1]. However, the research accumulated so far has mainly been focused on utilizing bidentate bisoxazoline derivatives in catalysis, leaving the monodentate oxazoline ligands widely unexplored. Syntheses of more complex organic molecules often demand introduction of protection groups due to the large number of functional groups, which react in a non-selective fashion with various reagents. The introduction of protecting groups can be avoided by careful choice of the reagents and adjustment of reaction conditions. Following our work on metal-organic catalysts in which noncovalent interactions induce chirality [2, 3] we have synthesized monodentate oxazoline ligands for application in asymmetric catalysis. In this study we present a comparison of synthetic approaches via protecting groups and the “one pot” method for asymmetric substitution of benzene and naphthalene rings with oxazoline and peptide substituents with different substitution patterns. The prepared compounds are characterized using spectroscopic methods, namely 1H and 13C NMR, as well as mass spectrometry.

Izvorni jezik
Hrvatski, engleski

Znanstvena područja
Kemija

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