Naslov
The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis

Autori
Habek, Mario ; Pucić, Dunja ; Mutak, Tomislav ; Crnošija, Luka ; Lovrić, Mila ; Krbot Skorić, Magdalena

Izvornik
Neurological Sciences (1590-1874) 41 (2020), 11; 3157-3164

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adrenergic hyperactivity ; Arterial hypertension ; Autonomic nervous system ; Comorbidities ; Multiple sclerosis

Sažetak
Objectives: To evaluate the evolution of adrenergic baroreflex sensitivity (BRSa) over 2-year follow-up and to investigate the effect of baseline BRSa indices on blood pressure values after 2 years in people with multiple sclerosis (pwMS). Methods: The following data were analysed at baseline and after 2 years: BRSa measured with BRSa1, α-BRSa and β-BRSa, supine and tilted levels of epinephrine and norepinephrine, supine and tilted systolic and diastolic blood pressure levels. Results: Compared to baseline values, there was no change in α-BRSa (6.96 ± 2.56 vs. 6.64 ± 2.24, p = 0.379) at month 24. α-BRSa at month 24 positively correlated with tilted levels of norepinephrine at month 24 (rp = 0.357, p = 0.005). Univariable linear regression analysis revealed that α-BRSa at baseline predicts the value of tilted systolic and diastolic blood pressure at month 24 (B = 2.724, 95% CI 1.357-4.091, p < 0.001 and B = 1.489, 95% CI 0.459-2.519, p = 0.005). Conclusion: This study provides further evidence for possible role of α-BRSa as a marker of adrenergic hyperactivity in pwMS. These results may explain increased risk for cardiovascular diseases in pwMS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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