Naslov
PR022: Cytomegalovirus and Epstein Barr Virus role in etiology and development of periodontal disease

Autori
Vražić, Domagoj ; Miovski, Zoran ; Strozzi, Maja ; Plančak, Darije ; Puhar, Ivan ; Badovinac, Ana ; Musić, Larisa ; Beader, Nataša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Abstracts of EuroPerio 9 Amsterdam, the Netherlands, 20- 23 June, 2018. U: Journal of clinical periodontology. 2018. br.S19 / - : John Wiley & Sons, 2018, 126-126

Skup
9th Congress of European Federation of Periodontology (EuroPerio 9)

Mjesto i datum
Amsterdam, Nizozemska, 20.06.2018. - 23.06.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cytomegalovirus ; epstein barr virus ; periodontitis
(citomegalovirus ; epstein barr virus ; parodontitis)

Sažetak
Background & Aim: Virus etiology of periodontal disease and its development was suggested by few studies through changing the host response to local subgingival microbiota. Our aim was to investigate a possible connection between Cytomegalovirus (CMV) and Epstein Barr Virus (EBV) with periodontal disease in patients with coronary heart disease. Methods: Subjects (n = 60) were recruited from hospitalized patients that had to do coronary angiography due to their primary illness at the University Hospital Centre Zagreb. A sample of peripheral venous blood (10 ml) was collected to perform the antibody titration analysis for CMV and EBV. The centrifuged serum was analyzed by VIDAS® (bioMérieux, http://www.biomerieux-diagnostics.com/) using ELFA method (Enzyme Linked Fluorescent Assay). Full periodontal examination and indices were measured. 52 samples were representative and were included in statistical analysis. Results: The presence of VCA IgM specific antibodies tells us about a recent primary infection with CMV and EBV, while the presence of VCA IgG specific antibodies is a sign of infection somewhere farther in the past. Of all subjects tested for specific antibodies for EBV and CMV, all of them were positive for EBV VCA IgG (100%), and most of them for CMV IgG (90.7%). For all subjects who were seropositive to VCA IgG and negative to VCA IgM, we can conclude that they had similar results: more than 60% of them had some form of periodontal disease, mostly 40% chronic periodontitis and 20% aggressive periodontitis. More than 60% had at least one pocket depth of 6 mm and above. Deeper pockets were significantly more frequent in a group that was VCA IgM negative, p < 0.05. If we look at known risk factors, male sex dominated with 80% and only 25% of subjects were never smokers. Conclusion: Development of periodontal disease might be associated with CMV and EBV infections, more frequently with chronic periodontitis, however further research is required.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Dentalna medicina

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