Naslov
Influence of Body Composition on Quality of Life (QoL) of Breast Cancer Patients Treated with Adjuvant Chemotherapy

Autori
Pavlović, MIrjana ; Lepetić, Petra ; Linarić, Petra ; Vazdar, Ljubica ; Tečić Vuger, Ana ; Šeparović, Robert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
14 hrvatski onkološki kongres 14th Croatian Oncology Congress / Eduard Vrdoljak, Marijana Jazvić - Zagreb : Klinika za tumore, Klinički bolnički centar Sestre milosrdnice Ilica 197, 10 000 Zagreb, 2021, 108-109

Skup
14 hrvatski onkološki kongres 14th Croatian Oncology Congress ; Virtual Congress

Mjesto i datum
Hrvatska, 22.04.2021. - 25.04.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Body composition ; Quality of life ; Breast cancer

Sažetak
Body composition has been studied relatively recently as part of oncology trials in different types of tumors. There are numerous studies that clearly define the impact of chemotherapy and its side effects on quality of life of breast cancer patients, however there have been few studies that have analysed the impact of body composition on chemotherapy tolerance as well as on the quality of life of premenopausal patients in the course of cytotoxic treatment. The study was performed on a consecutive sample of patients treated with neoadjuvant or adjuvant chemotherapy for early- stage breast cancer at the daily hospital of the Department of Medical Oncology of University hospital for Tumors in Zagreb between December 2018. and April 2019. All patients were premenopausal and received four cycles of doxorubicin + cyclophosphamide chemotherapy in standard dose, every three weeks, before or after the surgery. During the each visit patients filled standardized quality of life questionnaires (EORTC QLQ-C30 and QLQ-B23) and patient’s body composition was esti- mated using Tanita BC-420MA analyzer. The data were presented as averages with standard deviations for numeric data, or numbers and percentages for categorical data. The testing was performed with Pear- son’s correlation coefficient. All analyses were performed in R, with significance set at P<0.05. The study included 68 patients with median age of 52, 6 years (range 29- 55 years). Analysis of the results of body composition measurements in correlation with QoL showed the impact of body composi- tion on certain QoL subdomains during treatment. At the beginning of the study, at the first measurement, patients with higher body mass and increased visceral fat index have shown worse physical performance than other patients. During the entire study, sexual functioning in patients with higher visceral fat index was significantly reduced. In a later course of the study, it was shown that body composition significantly influenced the occurrence of fatigue during treatment, that is, that patients with a higher percentage of body fat and visceral fat index were significantly more tired than patients who had a higher percentage of muscle mass. In conclusion, our research showed significant correlation between some components of body com- position and QoL subdomains in premenopausal patients with early breast cancer treated with chemo- 108 Lib Oncol. 2021 ; 49(Suppl 1):83–140 therapy. This kind of information can be used in planning interventions for specific subgroup of patients which can bring an improvement in the patient’s well-being during chemotherapy, improve patient’s adherence to therapy and thus indirectly influence prognosis of the disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA