Naslov
Consumption of high-dose statins in patients older than 65 years in the Republic of Croatia in the period 2005 - 2015

Autori
Grgurević, Dijana ; Grgurević, Joško ; Bačić Vrca, Vesna ; Marušić, Srećko ; Marinović, Ivana

Izvornik
International journal of clinical pharmacology and therapeutics (0946-1965) 59 (2021), 2; 127-137

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
statins ; elderly patients

Sažetak
Objective: Patients over 65 years of age on high- dose statins are most sensitive to the development of adverse effects of statins. The objective of this study is to analyze the consumption of high- dose statins in this patient group in Croatia in the period of 2005 – 2015. Materials and methods: For the period of January 1, 2005 to December 31, 2015, the Croatian Institute for Health Insurance provided us with the total number of: all insured, insured over 65 years of age, insured using statins, insured using high-dose statins, insured over 65 using statins, insured over 65 using high- dose statins, number of packages dispensed through all community pharmacies for all statins registered in Croatia divided by year and sex. Studied high- dose statins were: simvastatin 40 mg ; atorvastatin 40 mg, 60 mg, 80 mg ; fluvastatin 80 mg ; rosuvastatin 40 mg. The yearly consumption of each form of statin was calculated in DDD/1, 000 insured/day and was statistically processed. Results: The consumption of all statins increased by 194%, while the consumption of high-dose statins in patients over 65 increased by 296%. The number of all patients on statin therapy increased by 58%, the number of patients over 65 on statin therapy increased by 87%, and the number of patients over 65 on high-dose statins increased by 326%. 60% of all patients over 65 receiving high- dose statins were women. The most used high-dose statins were atorvastatin and simvastatin. Conclusion: Consumption of all statins increased, mostly high-dose statins in the 65+ age group, the most sensitive population for adverse effects. The number of 65+ patients on high-dose statins grew much faster than the general statin user group, thus increasing the risk potential. Women are dominating all age and dose groups of statin users.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA