Naslov
Fluorescence spectroscopic study on the interaction of dopamine and L-dopa with different selenium nanoparticles

Autori
Kalčec, Nikolina ; Mamić, Ivan ; Peranić, Nikolina ; Vinković Vrček, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
EuroNanoForum 2021 Booklet of Abstracts / - , 2021, 109-109

Skup
EuroNanoForum 2021

Mjesto i datum
Braga, Portugal, 05.05.2021. - 06.05.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
selenium nanoparticles ; L-dopa ; dopamine ; fluorescence spectroscopy

Sažetak
The development of new strategies to treat Parkinson’s disease suffers from many deficiencies. Common therapy that includes external administration of L-dopa to Parkinson’s disease patients is limited due to the lack of targeting ability.[1, 2] As an alternative for conventional therapeutic drugs, selenium nanoparticles (SeNPs) constitute an attractive carrier platform for targeted drug delivery into the brain.[3, 4] In this study, two different SeNPs were designed using polyvinylpyrrolidone (PVP) and polysorbate 20 (Tween) as surface modifiers. Their binding ability for dopamine and L-dopa was evaluated by steady-state fluorescence spectroscopy. The strongest interaction was observed between L-dopa and PVP-SeNPs. Thermodynamic analysis revealed that binding between Tween-SeNPs and L-dopa or dopamine predominantly occurs through van der Waals interactions and hydrogen bonds, while electrostatic interactions govern the binding of L-dopa or dopamine to the PVP-SeNPs. In all cases, interactions were exothermic and spontaneous.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Farmacija

POVEZANOST RADA