Naslov
The genotoxic risk in health care workers occupationally exposed to cytotoxic drugs—A comprehensive evaluation by the SCE assay

Autori
Kopjar, Nevenka ; Kašuba, Vilena ; Rozgaj, Ružica ; Želježić, Davor ; Milić, Mirta ; Ramić, Snježana ; Pavlica, Vesna ; Milković Kraus, Sanja

Izvornik
Journal of environmental science and health. Part A : Toxic/hazardous substances & environmental engineering (1093-4529) 44 (2009); 462-479

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cytotoxic drugs ; occupational exposure ; sister chromatid exchanges ; lymphocytes ; genotoxicity

Sažetak
Present study aimed at an integral assessment of sister chromatid exchange (SCE) frequencies in the health careworkers occupationally exposed to cytostatics. The results of 500 individual analyses were evaluated. Drug handling practice was investigated in parallel and the results showed that cytostatics are mostly prepared outside hospital pharmacy (98%) and mainly handled by nurses (96%). Mean frequency of SCE was 5.63 ± 2.28, while HFC represented 9.65% of the cells analysed. Both values were higher compared to previously established control values for Croatian population. The duration of exposure, profession, age, gender, smoking habit, medical exposures, and simultaneous exposure to other occupational mutagens significantly contributed to SCE and HFC values. The usefulness both biomarkers in the assessment of cytogenetic damage is confirmed. Since current practice in Croatian hospitals does not include regular monitoring of workplaces, to ensure maximal occupational safety, a surveillance on exposed health care workers, including periodic biomonitoring, is recommended.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Farmacija

POVEZANOST RADA