Pregled bibliografske jedinice broj: 1126069
Profiling colorectal cancer in the landscape personalized testing—advantages of liquid biopsy
Profiling colorectal cancer in the landscape personalized testing—advantages of liquid biopsy // International journal of molecular sciences, 22 (2021), 9; 4327, 14 doi:10.3390/ijms22094327 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 1126069 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Profiling colorectal cancer in the landscape
personalized testing—advantages of liquid biopsy
Autori
Verbanac, Donatella ; Čeri, Andrea ; Hlapčić, Iva ; Shakibaei, Mehdi ; Brockmueller, Aranka ; Krušlin, Božo ; Ljubičić, Neven ; Baršić, Neven ; Detel, Dijana ; Batičić, Lara ; Rumora, Lada ; Somborac-Bačura, Anita ; Štefanović, Mario ; Ćelap, Ivana ; Demirović, Alma ; Petlevski, Roberta ; Petrik, József ; Grdić Rajković, Marija ; Hulina-Tomašković, Andrea ; Rako, Ivana ; Saso, Luciano ; Barišić, Karmela
Izvornik
International journal of molecular sciences (1422-0067) 22
(2021), 9;
4327, 14
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
biomarkers ; colorectal cancer ; early detection examination ; liquid biopsy ; personalized medicine ; tumor treatment ; exosomes ; ctDNA ; CTC
Sažetak
Drug‐specific therapeutic approaches for colorectal cancer (CRC) have contributed to significant improvements in patient health. Nevertheless, there is still a great need to improve the personalization of treatments based on genetic and epigenetic tumor profiles to maximize the quality and efficacy while limiting cytotoxicity. Currently, CEA and CA 19‐9 are the only validated blood biomarkers in clinical practice. For this reason, laboratories are trying to identify new specific prognostics and, more importantly, predictive biomarkers for CRC patient profiling. Thus, the unique landscape of personalized biomarker data should have a clinical impact on CRC treatment strategies and molecular genetic screening tests should become the standard method for diagnosing CRC. This review concentrates on recent molecular testing in CRC and discusses the potential modifications in CRC assay methodology with the upcoming clinical application of novel genomic approaches. While mechanisms for analyzing circulating tumor DNA have been proven too inaccurate, detecting and analyzing circulating tumor cells and protein analysis of exosomes represent more promising options. Blood liquid biopsy offers good prospects for the future if the results align with pathologists’ tissue analyses. Overall, early detection, accurate diagnosis and treatment monitoring for CRC with specific markers and targeted molecular testing may benefit many patients.
Izvorni jezik
Engleski
Znanstvena područja
Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti, Farmacija
POVEZANOST RADA
Projekti:
IP-2019-04-4624 - Gensko, proteinsko i RNA profiliranje kolorektalnog karcinoma primjenom tekuće biopsije (CRCMolProfil) (Barišić, Karmela, HRZZ - 2019-04) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Rijeka,
Stomatološki fakultet, Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb
Profili:
Ivana Rako
(autor)
Ivana Ćelap
(autor)
Neven Baršić
(autor)
Andrea Hulina Tomašković
(autor)
Neven Ljubičić
(autor)
Božo Krušlin
(autor)
Andrea Čeri
(autor)
Roberta Petlevski
(autor)
Anita Somborac Bačura
(autor)
Mario Štefanović
(autor)
Iva Hlapčić
(autor)
Alma Demirović
(autor)
Jozsef Petrik
(autor)
Donatella Verbanac
(autor)
Lara Batičić
(autor)
Dijana Detel
(autor)
Lada Rumora
(autor)
Karmela Barišić
(autor)
Marija Grdić Rajković
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE