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Pregled bibliografske jedinice broj: 1125953

Structural changes in the cortico-ponto- cerebellar axis at birth are associated with abnormal neurological outcomes in childhood


Raguž, Marina; Radoš, Milan; Kostović Srzentić, Mirna; Kovačić, Nataša; Žunić Išasegi, Iris; Benjak, Vesna; Ćaleta, Tomislav; Vukšić, Mario; Kostović, Ivica
Structural changes in the cortico-ponto- cerebellar axis at birth are associated with abnormal neurological outcomes in childhood // Clinical Neuroradiology, 31 (2021), 1005-1020 doi:10.1007/s00062-021-01017-1 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1125953 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Structural changes in the cortico-ponto- cerebellar axis at birth are associated with abnormal neurological outcomes in childhood

Autori
Raguž, Marina ; Radoš, Milan ; Kostović Srzentić, Mirna ; Kovačić, Nataša ; Žunić Išasegi, Iris ; Benjak, Vesna ; Ćaleta, Tomislav ; Vukšić, Mario ; Kostović, Ivica

Izvornik
Clinical Neuroradiology (1869-1439) 31 (2021); 1005-1020

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
brainstem ; MRI ; perinatal hypoxic-ischemic encephalopathy ; premature infant ; tractograophy

Sažetak
White matter lesions in hypoxic-ischemic encephalopathy (HIE) are considered to be the important substrate of frequent neurological consequences in preterm infants. The aim of the study was to analyze volumes and tractographic parameters of the cortico-ponto-cerebellar axis to assess alterations in the periventricular fiber system and crossroads, corticopontine and corticospinal pathways and prospective transsynaptic changes of the cerebellum.Term infants (control), premature infants without (normotypic) and with perinatal HIE (HIE) underwent brain magnetic resonance imaging at term-equivalent age (TEA) and at 2 years. Cerebrum, cerebellum, brainstem divisions and ventrodorsal compartments volumetric analysis were performed, as well as fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of corticopontine, corticospinal pathways and middle cerebellar peduncles. Amiel-Tison scale at TEA and the Hempel test at 2 years were assessed.Cerebellum, brainstem and its compartments volumes were decreased in normotypic and HIE groups at TEA, while at 2 years volumes were significantly reduced in the HIE group, accompanied by decreased volume and FA and increased ADC of corticopontine and corticospinal pathways. Negative association of the brainstem, cerebellum, mesencephalon, pons, corticopontine volumes and corticospinal pathway FA at TEA with the neurological score at 2 years. Cerebellum and pons volumes presented as potential prognostic indicators of neurological outcomes.Our findings agree that these pathways, as a part of the periventricular fiber system and crossroads, exhibit lesion-induced reaction and vulnerability in HIE. Structural differences between normotypic and HIE group at the 2 years suggest a different developmental structural plasticity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
--IP-2013-11-7379 - Histološka, MRI i analiza genske ekspresije reorganizacijskih procesa u medijalnom (limbičkom) zidu ljudskog mozga tijekom razvitka (MEDCEREB) (Vukšić, Mario) ( CroRIS)
--KK.01.1.1.01.0007 - Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi (ZCI Neuro) (Judaš, Miloš) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb,
Zdravstveno veleučilište, Zagreb

Poveznice na cjeloviti tekst rada:

doi link.springer.com

Citiraj ovu publikaciju:

Raguž, Marina; Radoš, Milan; Kostović Srzentić, Mirna; Kovačić, Nataša; Žunić Išasegi, Iris; Benjak, Vesna; Ćaleta, Tomislav; Vukšić, Mario; Kostović, Ivica
Structural changes in the cortico-ponto- cerebellar axis at birth are associated with abnormal neurological outcomes in childhood // Clinical Neuroradiology, 31 (2021), 1005-1020 doi:10.1007/s00062-021-01017-1 (međunarodna recenzija, članak, znanstveni)
Raguž, M., Radoš, M., Kostović Srzentić, M., Kovačić, N., Žunić Išasegi, I., Benjak, V., Ćaleta, T., Vukšić, M. & Kostović, I. (2021) Structural changes in the cortico-ponto- cerebellar axis at birth are associated with abnormal neurological outcomes in childhood. Clinical Neuroradiology, 31, 1005-1020 doi:10.1007/s00062-021-01017-1.
@article{article, author = {Ragu\v{z}, Marina and Rado\v{s}, Milan and Kostovi\'{c} Srzenti\'{c}, Mirna and Kova\v{c}i\'{c}, Nata\v{s}a and \v{Z}uni\'{c} I\v{s}asegi, Iris and Benjak, Vesna and \'{C}aleta, Tomislav and Vuk\v{s}i\'{c}, Mario and Kostovi\'{c}, Ivica}, year = {2021}, pages = {1005-1020}, DOI = {10.1007/s00062-021-01017-1}, keywords = {brainstem, MRI, perinatal hypoxic-ischemic encephalopathy, premature infant, tractograophy}, journal = {Clinical Neuroradiology}, doi = {10.1007/s00062-021-01017-1}, volume = {31}, issn = {1869-1439}, title = {Structural changes in the cortico-ponto- cerebellar axis at birth are associated with abnormal neurological outcomes in childhood}, keyword = {brainstem, MRI, perinatal hypoxic-ischemic encephalopathy, premature infant, tractograophy} }
@article{article, author = {Ragu\v{z}, Marina and Rado\v{s}, Milan and Kostovi\'{c} Srzenti\'{c}, Mirna and Kova\v{c}i\'{c}, Nata\v{s}a and \v{Z}uni\'{c} I\v{s}asegi, Iris and Benjak, Vesna and \'{C}aleta, Tomislav and Vuk\v{s}i\'{c}, Mario and Kostovi\'{c}, Ivica}, year = {2021}, pages = {1005-1020}, DOI = {10.1007/s00062-021-01017-1}, keywords = {brainstem, MRI, perinatal hypoxic-ischemic encephalopathy, premature infant, tractograophy}, journal = {Clinical Neuroradiology}, doi = {10.1007/s00062-021-01017-1}, volume = {31}, issn = {1869-1439}, title = {Structural changes in the cortico-ponto- cerebellar axis at birth are associated with abnormal neurological outcomes in childhood}, keyword = {brainstem, MRI, perinatal hypoxic-ischemic encephalopathy, premature infant, tractograophy} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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