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Pregled bibliografske jedinice broj: 1125869

In a rat model of ageing, long term treatment with wine antioxidant, resveratrol, upregulates plasma levels of testosterone in males and downregulates plasma levels of progesterone in females


Sabolić, Ivan; Micek, Vedran; Gerić, Marko; Gajski, Goran; Kralik Oguić, Saša; Rašić, Dubravka; Karaica, Dean; Vrhovac Madunić, Ivana; Ljubojević, Marija; Orct, Tatjana et al.
In a rat model of ageing, long term treatment with wine antioxidant, resveratrol, upregulates plasma levels of testosterone in males and downregulates plasma levels of progesterone in females // Abstract Book -1st Science & Wine World Congress
Porto, Portugal, 2019. str. 28-28 (predavanje, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1125869 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
In a rat model of ageing, long term treatment with wine antioxidant, resveratrol, upregulates plasma levels of testosterone in males and downregulates plasma levels of progesterone in females

Autori
Sabolić, Ivan ; Micek, Vedran ; Gerić, Marko ; Gajski, Goran ; Kralik Oguić, Saša ; Rašić, Dubravka ; Karaica, Dean ; Vrhovac Madunić, Ivana ; Ljubojević, Marija ; Orct, Tatjana ; Jurasović, Jasna ; Novak Jovanović, Ivana ; Peraica, Maja ; Nanić, Lucia ; Rubelj, I ; Breljak, Davorka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book -1st Science & Wine World Congress / - , 2019, 28-28

Skup
1st Science & Wine World Congress

Mjesto i datum
Porto, Portugal, 08.05.2019. - 10.05.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Rat ; Resveratrol ; Testosterone ; Plasma

Sažetak
Introduction: Aging-related impaired body structure and functions are assumed to be, at least partially, caused by elevated oxidative stress (OS). A red wine polyphenol resveratrol may act as an antioxidant and anti-aging medium, but its actions in vivo are controversial (1). Here we report on sex- related effects of resveratrol treatment (RT) on blood/plasma parameters of DNA damage, oxidative status, and concentrations of sex hormones (SH) in a rat model of aging (2). Material & Methods: Starting from their age of 3-mo, for the next 9-mo or 21-mo male and female Wistar rats were drinking resveratrol in water (10 mg/L ; predicted intake: ~1 mg/kg b.m./day) or only water (controls). In their blood/plasma we performed the alkaline comet assay (3) and determined glutathione (4) and malondialdehyde (5) by the established methods. SH were determined by commercial kits. Results: Compared with controls, the 9-mo RT did not change any parameter in both sexes. After the 21-mo RT, the OS-related parameters remained unchanged, but testosterone levels in males were ⁓45% higher (P<0.001), and progesterone levels in females were ⁓40% (P<0.01) lower. Conclusion: In old rats, a long-term RT does not change the OS-related parameters in blood/plasma, but it affects the levels of SH. References 1. J. Gambini et al. Properties of resveratrol: in vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans. Oxid. Med. Cell. Longev., Volume 2015, Article ID 837042, 13 pages, http://dx.doi.org/10.1155/2015/837042 2. Croatian Science Foundation project IP- 2013-11-1481 3. N.P. Singh et al. A simple technique for quantitation of low levels of DNA damage in individual cells, Exp. Cell Res. 175 (1988) 184–191. 4. G.L. Ellman. A colorimetric method for determining low concentrations of mercaptans, Arch. Biochem. Biophys. 74 (1958) 443-450. 5. J.A. Drury et al. Comparison of urinary and plasma malondialdehyde in preterm infants, Clin. Chim. Acta 263 (1997) 177-185.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
IP-2013-11-1481 - Starosno-ovisna ekspresija membranskih prijenosnika u štakora (AGEMETAR) (Sabolić, Ivan, HRZZ - 2013-11) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Klinički bolnički centar Zagreb


Citiraj ovu publikaciju:

Sabolić, Ivan; Micek, Vedran; Gerić, Marko; Gajski, Goran; Kralik Oguić, Saša; Rašić, Dubravka; Karaica, Dean; Vrhovac Madunić, Ivana; Ljubojević, Marija; Orct, Tatjana et al.
In a rat model of ageing, long term treatment with wine antioxidant, resveratrol, upregulates plasma levels of testosterone in males and downregulates plasma levels of progesterone in females // Abstract Book -1st Science & Wine World Congress
Porto, Portugal, 2019. str. 28-28 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Sabolić, I., Micek, V., Gerić, M., Gajski, G., Kralik Oguić, S., Rašić, D., Karaica, D., Vrhovac Madunić, I., Ljubojević, M. & Orct, T. (2019) In a rat model of ageing, long term treatment with wine antioxidant, resveratrol, upregulates plasma levels of testosterone in males and downregulates plasma levels of progesterone in females. U: Abstract Book -1st Science & Wine World Congress.
@article{article, author = {Saboli\'{c}, Ivan and Micek, Vedran and Geri\'{c}, Marko and Gajski, Goran and Kralik Ogui\'{c}, Sa\v{s}a and Ra\v{s}i\'{c}, Dubravka and Karaica, Dean and Vrhovac Maduni\'{c}, Ivana and Ljubojevi\'{c}, Marija and Orct, Tatjana and Jurasovi\'{c}, Jasna and Novak Jovanovi\'{c}, Ivana and Peraica, Maja and Nani\'{c}, Lucia and Rubelj, I and Breljak, Davorka}, year = {2019}, pages = {28-28}, keywords = {Rat, Resveratrol, Testosterone, Plasma}, title = {In a rat model of ageing, long term treatment with wine antioxidant, resveratrol, upregulates plasma levels of testosterone in males and downregulates plasma levels of progesterone in females}, keyword = {Rat, Resveratrol, Testosterone, Plasma}, publisherplace = {Porto, Portugal} }
@article{article, author = {Saboli\'{c}, Ivan and Micek, Vedran and Geri\'{c}, Marko and Gajski, Goran and Kralik Ogui\'{c}, Sa\v{s}a and Ra\v{s}i\'{c}, Dubravka and Karaica, Dean and Vrhovac Maduni\'{c}, Ivana and Ljubojevi\'{c}, Marija and Orct, Tatjana and Jurasovi\'{c}, Jasna and Novak Jovanovi\'{c}, Ivana and Peraica, Maja and Nani\'{c}, Lucia and Rubelj, I and Breljak, Davorka}, year = {2019}, pages = {28-28}, keywords = {Rat, Resveratrol, Testosterone, Plasma}, title = {In a rat model of ageing, long term treatment with wine antioxidant, resveratrol, upregulates plasma levels of testosterone in males and downregulates plasma levels of progesterone in females}, keyword = {Rat, Resveratrol, Testosterone, Plasma}, publisherplace = {Porto, Portugal} }




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