Pregled bibliografske jedinice broj: 1125869
In a rat model of ageing, long term treatment with wine antioxidant, resveratrol, upregulates plasma levels of testosterone in males and downregulates plasma levels of progesterone in females
In a rat model of ageing, long term treatment with wine antioxidant, resveratrol, upregulates plasma levels of testosterone in males and downregulates plasma levels of progesterone in females // Abstract Book -1st Science & Wine World Congress
Porto, Portugal, 2019. str. 28-28 (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1125869 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
In a rat model of ageing, long term treatment
with wine antioxidant, resveratrol, upregulates
plasma levels of testosterone in males and
downregulates plasma levels of progesterone in
females
Autori
Sabolić, Ivan ; Micek, Vedran ; Gerić, Marko ; Gajski, Goran ; Kralik Oguić, Saša ; Rašić, Dubravka ; Karaica, Dean ; Vrhovac Madunić, Ivana ; Ljubojević, Marija ; Orct, Tatjana ; Jurasović, Jasna ; Novak Jovanović, Ivana ; Peraica, Maja ; Nanić, Lucia ; Rubelj, I ; Breljak, Davorka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstract Book -1st Science & Wine World Congress
/ - , 2019, 28-28
Skup
1st Science & Wine World Congress
Mjesto i datum
Porto, Portugal, 08.05.2019. - 10.05.2019
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Rat ; Resveratrol ; Testosterone ; Plasma
Sažetak
Introduction: Aging-related impaired body structure and functions are assumed to be, at least partially, caused by elevated oxidative stress (OS). A red wine polyphenol resveratrol may act as an antioxidant and anti-aging medium, but its actions in vivo are controversial (1). Here we report on sex- related effects of resveratrol treatment (RT) on blood/plasma parameters of DNA damage, oxidative status, and concentrations of sex hormones (SH) in a rat model of aging (2). Material & Methods: Starting from their age of 3-mo, for the next 9-mo or 21-mo male and female Wistar rats were drinking resveratrol in water (10 mg/L ; predicted intake: ~1 mg/kg b.m./day) or only water (controls). In their blood/plasma we performed the alkaline comet assay (3) and determined glutathione (4) and malondialdehyde (5) by the established methods. SH were determined by commercial kits. Results: Compared with controls, the 9-mo RT did not change any parameter in both sexes. After the 21-mo RT, the OS-related parameters remained unchanged, but testosterone levels in males were ⁓45% higher (P<0.001), and progesterone levels in females were ⁓40% (P<0.01) lower. Conclusion: In old rats, a long-term RT does not change the OS-related parameters in blood/plasma, but it affects the levels of SH. References 1. J. Gambini et al. Properties of resveratrol: in vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans. Oxid. Med. Cell. Longev., Volume 2015, Article ID 837042, 13 pages, http://dx.doi.org/10.1155/2015/837042 2. Croatian Science Foundation project IP- 2013-11-1481 3. N.P. Singh et al. A simple technique for quantitation of low levels of DNA damage in individual cells, Exp. Cell Res. 175 (1988) 184–191. 4. G.L. Ellman. A colorimetric method for determining low concentrations of mercaptans, Arch. Biochem. Biophys. 74 (1958) 443-450. 5. J.A. Drury et al. Comparison of urinary and plasma malondialdehyde in preterm infants, Clin. Chim. Acta 263 (1997) 177-185.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
IP-2013-11-1481 - Starosno-ovisna ekspresija membranskih prijenosnika u štakora (AGEMETAR) (Sabolić, Ivan, HRZZ - 2013-11) ( CroRIS)
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Klinički bolnički centar Zagreb
Profili:
Ivan Sabolić
(autor)
Marija Ljubojević
(autor)
Dean Karaica
(autor)
Ivana Vrhovac Madunić
(autor)
SAŠA KRALIK OGUIĆ
(autor)
Maja Peraica
(autor)
Tatjana Orct
(autor)
Jasna Jurasović
(autor)
Davorka Breljak
(autor)
Lucia Nanić
(autor)
Dubravka Rašić
(autor)
Goran Gajski
(autor)
Ivana Novak Jovanović
(autor)
Ivica Rubelj
(autor)
Marko Gerić
(autor)