Pregled bibliografske jedinice broj: 1124798
The mode of antibacterial action of quaternary N-benzylimidazole salts against emerging opportunistic pathogens
The mode of antibacterial action of quaternary N-benzylimidazole salts against emerging opportunistic pathogens // Bioorganic chemistry, 112 (2021), 104938, 8 doi:10.1016/j.bioorg.2021.104938 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1124798 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The mode of antibacterial action of quaternary N-benzylimidazole salts against emerging opportunistic pathogens
Autori
Crnčević, Doris ; Krce, Lucija ; Mastelić, Linda ; Maravić, Ana ; Soldo, Barbara ; Aviani, Ivica ; Primožič, Ines ; Odžak, Renata ; Šprung, Matilda
Izvornik
Bioorganic chemistry (0045-2068) 112
(2021);
104938, 8
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
quaternary ammonium compounds ; mode of action ; emerging pathogens ; benzylimidazolium compounds ; antimicrobial activity ; cytotoxicity
Sažetak
Quaternary ammonium compounds (QACs) are antimicrobial agents displaying a broad spectrum of activity due to their mechanism of action targeting the bacterial membrane. The emergence of bacterial resistance to QACs, especially in times of pandemics, requires the continuous search for new and potent QACs structures. Here we report the synthesis and biological evaluation of QACs based on imidazole derivative, N-benzylimidazole. The antimicrobial activity was tested against a range of pathogenic bacteria and fungi, both ATCC and clinical isolates, showing varying activities ranging in minimal inhibitory concentrations (MICs) from as low as 7 ng/mL. The most promising compound, N-tetradecyl derivative (BnI-14), proved to be very potent against bacterial biofilms, even at sub-MIC doses, suggesting interference with the bacterial growth and/or division process. The BnI-14 treatment induces bacterial membrane disruption, as observed by fluorescence spectroscopy and atomic force microscopy and it also binds to DNA indicating that bacterial membrane might not be the only cellular target of QACs. Most importantly, BnI-14 exhibits low toxicity to healthy human cell lines, suggesting that N- benzylimidazolium-based QACs may be promising new antimicrobial agents.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-UIP-2020-02-2356 - Otkriće i razvoj novih biološki aktivnih kvaternih amonijevih spojeva derivata kinuklidina (QACBioAct) (Šprung, Matilda, HRZZ ) ( CroRIS)
EK-KF-KK.01.1.1.01.0003 - STIM-REI (STIM-REI) (Bonačić-Koutecky, Vlasta; Smital, Tvrtko; Orlić, Sandi, EK - KK.01.1.1.01) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Split
Profili:
Ivica Aviani
(autor)
Matilda Šprung
(autor)
Renata Odžak
(autor)
Linda Mastelić
(autor)
Doris Crnčević
(autor)
Barbara Soldo
(autor)
Ana Maravić
(autor)
Lucija Krce
(autor)
Ines Primožič
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE