Pregled bibliografske jedinice broj: 1124218
Sex-related response of mice to silver nanoparticles after sub-acute exposure
Sex-related response of mice to silver nanoparticles after sub-acute exposure // NanoTox 2021 virtual conference : book of abstracts
Edinburgh, 2021. str. 181-182 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1124218 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Sex-related response of mice to silver nanoparticles
after sub-acute exposure
Autori
Božičević, Lucija ; Barbir, Rinea ; Goessler, Walter ; Micek, Vedran ; Debeljak, Željko ; Pavičić, Ivan ; Ćurlin, Marija ; Gorup, Dunja ; Vinković Vrček, Ivana ; Tariba Lovaković, Blanka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
NanoTox 2021 virtual conference : book of abstracts
/ - Edinburgh, 2021, 181-182
Skup
10th International conference on nanotoxicology (NanoTox 2021)
Mjesto i datum
Online, 20.04.2021. - 22.04.2021
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
AgNPs ; sex-related response ; in vivo
Sažetak
Introduction The extensive use of silver nanoparticles (AgNPs) represents a public concern in regards to safety and health risk (1). Production of reactive oxygen species (ROS) has been considered as one of the molecular initiating event linked to their mode of action (2 - 4). Some studies reported that adverse health effects of AgNPs could depend greatly on the formation of protein corona (5 - 8). We aimed to investigate the sex-related differences in the biodistribution and oxidative stress response in adult mice after sub-acute exposure to low-doses of polymer- vs. protein-stabilized AgNPs. Results Intact and gonadectomised male and female mice were treated intraperitoneally with polyvinylpyrrolidone (PVP)- coated or transferrin (TRF)-coated AgNPs in a dose of 1 mg Ag/kg b.w. during 21 day. After treatment, the Ag levels and oxidative stress biomarkers were determined in different tissues. In addition, changes in steroid hormone (aldosterone, cortisone, corticosterone, testosterone, androstendione, progesterone, dehidroepiandrostendione and 11- deoxicorticosterone) serum levels were measured . Sex-related differences were observed in tested parameters in almost all tissues. Concentration of Ag was significantly higher in the liver of females compared to males, and in the lungs of intact males compared to gonadectomised group. The most evident difference was in lungs where female mice responded more intensively to AgNPs exposure. There were no significant differences in levels of hormones in the AgNP-exposed animals compared to controls. Conclusions The AgNP distribution and toxicity effects are sex-related. Protein corona did not prevent oxidative stress, but induced a sharper response compared to PVP-AgNPs.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Farmacija
POVEZANOST RADA
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek
Profili:
Marija Ćurlin
(autor)
Željko Debeljak
(autor)
Blanka Tariba
(autor)
Ivana Vinković Vrček
(autor)
Lucija Božičević
(autor)
Dunja Gorup
(autor)
Rinea Barbir
(autor)
Ivan Pavičić
(autor)