Naslov
Diverse SARS-CoV-2 variants preceded the initial COVID-19 outbreak in Croatia

Autori
Rokić, Filip ; Trgovec-Greif, Lovro ; Sučić, Neven ; Čemeljić, Noa ; Grbeša Cekinović, Đurđica ; Svedružić, Željko ; Rukavina, Tomislav ; Vugrek, Oliver ; Jurak, Igor

Izvornik
Archives of virology (0304-8608) 166 (2021); 1735-1739

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
SARS-CoV-2 ; Croatia

Sažetak
We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS- CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with different SARS-CoV-2 variants belonging to different clades (mostly G and GH). This result confirms that there was widespread virus transmission early in 2020. Interestingly, we identified a unique mutation resulting in a V13I substitution in Nsp5A, the main viral protease, in a patient who had not received antiviral therapy.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Javno zdravstvo i zdravstvena zaštita, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA