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Pregled bibliografske jedinice broj: 1117156

Gene duplications trace mitochondria to the onset of eukaryote complexity


Tria, Fernando D K; Brueckner, Julia; Skejo, Josip; Xavier, Joana C; Kapust, Nils; Knopp, Michael; Wimmer, Jessica L E; Nagies, Falk S P; Zimorski, Verena; Gould, Sven B et al.
Gene duplications trace mitochondria to the onset of eukaryote complexity // Genome Biology and Evolution, 13 (2021), 5; 1-17 doi:10.1093/gbe/evab055 (međunarodna recenzija, članak, znanstveni)


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Naslov
Gene duplications trace mitochondria to the onset of eukaryote complexity

Autori
Tria, Fernando D K ; Brueckner, Julia ; Skejo, Josip ; Xavier, Joana C ; Kapust, Nils ; Knopp, Michael ; Wimmer, Jessica L E ; Nagies, Falk S P ; Zimorski, Verena ; Gould, Sven B ; Garg, Sriram G ; Martin, William F

Izvornik
Genome Biology and Evolution (1759-6653) 13 (2021), 5; 1-17

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
evolution, paralogy, gene transfer, endosymbiosis, gene duplication, eukaryote origin

Sažetak
The last eukaryote common ancestor (LECA) possessed mitochondria and all key traits that make eukaryotic cells more complex than their prokaryotic ancestors, yet the timing of mitochondrial acquisition and the role of mitochondria in the origin of eukaryote complexity remain debated. Here we report evidence from gene duplications in LECA indicating an early origin of mitochondria. Among 163, 545 duplications in 24, 571 gene trees spanning 150 sequenced eukaryotic genomes, we identify 713 gene duplication events that occurred in LECA. LECA's bacterial derived genes include numerous mitochondrial functions and were duplicated significantly more often than archaeal derived and eukaryote specific genes. The surplus of bacterial derived duplications in LECA most likely reflects the serial copying of genes from the mitochondrial endosymbiont to the archaeal host's chromosomes. Clustering, phylogenies and likelihood ratio tests for 22.4 million genes from 5, 655 prokaryotic and 150 eukaryotic genomes reveal no evidence for lineage specific gene acquisitions in eukaryotes, except from the plastid in the plant lineage. That finding, and the functions of bacterial genes duplicated in LECA, suggest that the bacterial genes in eukaryotes are acquisitions from the mitochondrion, followed by vertical gene evolution and differential loss across eukaryotic lineages, flanked by concomitant lateral gene transfer among prokaryotes. Overall, the data indicate that recurrent gene transfer via the copying of genes from a resident mitochondrial endosymbiont to archaeal host chromosomes preceded the onset of eukaryotic cellular complexity, favoring mitochondria-early over mitochondria-late hypotheses for eukaryote origin.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Josip Skejo (autor)

Citiraj ovu publikaciju:

Tria, Fernando D K; Brueckner, Julia; Skejo, Josip; Xavier, Joana C; Kapust, Nils; Knopp, Michael; Wimmer, Jessica L E; Nagies, Falk S P; Zimorski, Verena; Gould, Sven B et al.
Gene duplications trace mitochondria to the onset of eukaryote complexity // Genome Biology and Evolution, 13 (2021), 5; 1-17 doi:10.1093/gbe/evab055 (međunarodna recenzija, članak, znanstveni)
Tria, F., Brueckner, J., Skejo, J., Xavier, J., Kapust, N., Knopp, M., Wimmer, J., Nagies, F., Zimorski, V. & Gould, S. (2021) Gene duplications trace mitochondria to the onset of eukaryote complexity. Genome Biology and Evolution, 13 (5), 1-17 doi:10.1093/gbe/evab055.
@article{article, author = {Tria, Fernando D K and Brueckner, Julia and Skejo, Josip and Xavier, Joana C and Kapust, Nils and Knopp, Michael and Wimmer, Jessica L E and Nagies, Falk S P and Zimorski, Verena and Gould, Sven B and Garg, Sriram G and Martin, William F}, year = {2021}, pages = {1-17}, DOI = {10.1093/gbe/evab055}, keywords = {evolution, paralogy, gene transfer, endosymbiosis, gene duplication, eukaryote origin}, journal = {Genome Biology and Evolution}, doi = {10.1093/gbe/evab055}, volume = {13}, number = {5}, issn = {1759-6653}, title = {Gene duplications trace mitochondria to the onset of eukaryote complexity}, keyword = {evolution, paralogy, gene transfer, endosymbiosis, gene duplication, eukaryote origin} }
@article{article, author = {Tria, Fernando D K and Brueckner, Julia and Skejo, Josip and Xavier, Joana C and Kapust, Nils and Knopp, Michael and Wimmer, Jessica L E and Nagies, Falk S P and Zimorski, Verena and Gould, Sven B and Garg, Sriram G and Martin, William F}, year = {2021}, pages = {1-17}, DOI = {10.1093/gbe/evab055}, keywords = {evolution, paralogy, gene transfer, endosymbiosis, gene duplication, eukaryote origin}, journal = {Genome Biology and Evolution}, doi = {10.1093/gbe/evab055}, volume = {13}, number = {5}, issn = {1759-6653}, title = {Gene duplications trace mitochondria to the onset of eukaryote complexity}, keyword = {evolution, paralogy, gene transfer, endosymbiosis, gene duplication, eukaryote origin} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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