Naslov
Antioxidative activity and cytotoxicity quaternary salts of pyridinium-4-aldoxime

Autori
Crnčević, Doris ; Odžak, Renata ; Šprung, Matilda

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
The 3rd Mini-symposium of Medicinal and Pharmaceutical Chemistry for Young Scientist

Mjesto i datum
Zagreb, Hrvatska, 12.11.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
pyridine-4-aldoxime ; antioxidative activity ; cytotoxicity

Sažetak
Oximes are reactivators of phosphylated acetylcholinesterase (AChE ; EC 3.1.1.7) and therefore used in the therapy of poisoning by organophosphorus compounds (Dawson, 1994 ; Primožič et al., 2004). Quaternary salts (QACs) are group of chemical compounds with broad- spectrum applications. The most extensively studied biological property of QACs is antimicrobial activity and therefore, we have synthesized and investigated two monoquaternary N-benzyl-4-hydroxyiminomethylpyridinium bromides with diverse substituents introduced into the phenyl ring (Py-4-Br, Py-4-F). Our results show that both QACs have no significant antimicrobial activity as compared with commercial QACs. However, both compounds have been shown to inhibit Aspergillus niger growth (MIC50=62.5 g mL-1). The antioxidative activity of Py-4-Br and Py-4-F was investigated by ORAC and DNA nicking assays showing good antioxidative activity for both candidates. Cytotoxicity was assessed on three healthy human cell lines (HEK293, RPE1 and HaCat). The obtained results show no toxic activity for Py- 4-Br and Py-4-F, suggesting that these compounds could be possible new antimycotic reagents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA