Naslov
Effect of Atrazine and Zearalone on the Number of Receptor Binding Sites for 3H-Estradiol in the Rat Uterus Cytosol

Autori
Mitak, Mario ; Gojmerac, Tihomira ; Cvrtila, Drago ; Cvetnić, Željko

Izvornik
Veterinarni Medicina (0375-8427) 47 (2002), 1; 12-16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Atrazine; Zearalenone; 3H-estradiol receptor; Ovary; Uterus; Rat

Sažetak
The effect of a daily dose of 14 mg atrazine and/or2.5 mg zearalenone that were administered to rats during 5 days of estrous cycle on the number of receptor binding sites for 3H-estradiol in uterine cytosol was investigated. Comparison with a control group of animals showed no effect of atrazine influence on the number of receptor binding sites for 3H-estradiol in the rat uterine cytosol until day 6 of the experiment, when a significantly lower value was recorded (p<0.05). In the group of animals administered zearalenone, a decline in the number of receptor binding sites for 3H-estradiol in uterine cytosol was observed. On day 4 of the experiment, the number of binding sites was significantly greater (p<0.05) in this group than in the control group of animals, whereafter it gradually decreased to a significantly lower value (p<0.05) as compared to the control group on day 6. In the group of animals administered a mixture of atrazine and zearalenone, the number of receptor binding sites for 3H-estradiol in uterine cytosol did not decrease but showed a similar pattern as in the control group of animals, however, at a statistically significantly (p<0.05) higher level.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA