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Pregled bibliografske jedinice broj: 1115348

Higher serum uric acid is associated with higher risks of thrombosis and death in patients with primary myelofibrosis


Lucijanić, Marko; Krečak, Ivan; Galušić, Davor; Sedinić, Martina; Holik Hrvoje; Periša, Vlatka; Morić Perić, Martina; Zekanović, Ivan; Štoos- Veić, Tajana; Pejša, Vlatko; Kušec, Rajko
Higher serum uric acid is associated with higher risks of thrombosis and death in patients with primary myelofibrosis // Wiener klinische Wochenschrift, 133 (2021), 3-4; 97-103 doi:10.1007/s00508-020-01802-x (međunarodna recenzija, članak, znanstveni)


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Naslov
Higher serum uric acid is associated with higher risks of thrombosis and death in patients with primary myelofibrosis

Autori
Lucijanić, Marko ; Krečak, Ivan ; Galušić, Davor ; Sedinić, Martina ; Holik Hrvoje ; Periša, Vlatka ; Morić Perić, Martina ; Zekanović, Ivan ; Štoos- Veić, Tajana ; Pejša, Vlatko ; Kušec, Rajko

Izvornik
Wiener klinische Wochenschrift (0043-5325) 133 (2021), 3-4; 97-103

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mortality ; osteomyelofibrosis ; philadelphia chromosome negative myeloproliferative neoplasm ; prognosis ; thrombotic event

Sažetak
Background: Serum uric acid (SUA) can promote inflammation and is associated with increased cardiovascular morbidity. Primary (PMF) and secondary myelofibrosis (SMF) are myeloproliferative neoplasms characterized by high cellular turnover and substantial risk of thrombosis and death. Methods: We have retrospectively investigated SUA in 173 patients with myelofibrosis (125 PMF ; 48 SMF) and 30 controls. Results: The PMF patients had significantly higher SUA in comparison to SMF and controls. In both PMF and SMF higher SUA was significantly associated with arterial hypertension and decreased renal function. Among PMF patients, higher SUA was significantly associated with older age, larger spleen, higher white blood cell counts, higher lactate dehydrogenase, lower immunoglobulin G levels, allopurinol use and non-smoking. Among SMF patients, higher SUA was associated with male sex (P < 0.05 for all analyses). In PMF higher SUA was univariately associated with inferior survival (> 427 μmol/L hazard ratio (HR) = 2.22 ; P = 0.006) and shorter time to thrombosis (> 444 μmol/L HR = 5.05 ; P = 0.006), which could be shown separately for arterial (> 380 μmol/L ; HR = 4.9 ; P = 0.013) and venous thromboses (> 530 μmol/L ; HR = 17.9 ; P < 0.001). In multivariate analyses, SUA remained significantly associated with inferior survival independent of the Dynamic International Prognostic Staging System and with shorter time to thrombosis independent of age in PMF patients ; however, the prognostic significance of SUA was diminished after including serum creatinine in the models. SUA was not prognostic in SMF patients. Conclusion: The PMF patients present with higher SUA levels, which are associated with features of more advanced disease and higher risks of arterial and venous thrombosis and death.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Klinička bolnica "Dubrava",
Medicinski fakultet, Split,
Medicinski fakultet, Osijek

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi link.springer.com

Citiraj ovu publikaciju:

Lucijanić, Marko; Krečak, Ivan; Galušić, Davor; Sedinić, Martina; Holik Hrvoje; Periša, Vlatka; Morić Perić, Martina; Zekanović, Ivan; Štoos- Veić, Tajana; Pejša, Vlatko; Kušec, Rajko
Higher serum uric acid is associated with higher risks of thrombosis and death in patients with primary myelofibrosis // Wiener klinische Wochenschrift, 133 (2021), 3-4; 97-103 doi:10.1007/s00508-020-01802-x (međunarodna recenzija, članak, znanstveni)
Lucijanić, M., Krečak, I., Galušić, D., Sedinić, M., Holik Hrvoje, Periša, V., Morić Perić, M., Zekanović, I., Štoos- Veić, T., Pejša, V. & Kušec, R. (2021) Higher serum uric acid is associated with higher risks of thrombosis and death in patients with primary myelofibrosis. Wiener klinische Wochenschrift, 133 (3-4), 97-103 doi:10.1007/s00508-020-01802-x.
@article{article, author = {Lucijani\'{c}, Marko and Kre\v{c}ak, Ivan and Galu\v{s}i\'{c}, Davor and Sedini\'{c}, Martina and Peri\v{s}a, Vlatka and Mori\'{c} Peri\'{c}, Martina and Zekanovi\'{c}, Ivan and \v{S}toos- Vei\'{c}, Tajana and Pej\v{s}a, Vlatko and Ku\v{s}ec, Rajko}, year = {2021}, pages = {97-103}, DOI = {10.1007/s00508-020-01802-x}, keywords = {mortality, osteomyelofibrosis, philadelphia chromosome negative myeloproliferative neoplasm, prognosis, thrombotic event}, journal = {Wiener klinische Wochenschrift}, doi = {10.1007/s00508-020-01802-x}, volume = {133}, number = {3-4}, issn = {0043-5325}, title = {Higher serum uric acid is associated with higher risks of thrombosis and death in patients with primary myelofibrosis}, keyword = {mortality, osteomyelofibrosis, philadelphia chromosome negative myeloproliferative neoplasm, prognosis, thrombotic event} }
@article{article, author = {Lucijani\'{c}, Marko and Kre\v{c}ak, Ivan and Galu\v{s}i\'{c}, Davor and Sedini\'{c}, Martina and Peri\v{s}a, Vlatka and Mori\'{c} Peri\'{c}, Martina and Zekanovi\'{c}, Ivan and \v{S}toos- Vei\'{c}, Tajana and Pej\v{s}a, Vlatko and Ku\v{s}ec, Rajko}, year = {2021}, pages = {97-103}, DOI = {10.1007/s00508-020-01802-x}, keywords = {mortality, osteomyelofibrosis, philadelphia chromosome negative myeloproliferative neoplasm, prognosis, thrombotic event}, journal = {Wiener klinische Wochenschrift}, doi = {10.1007/s00508-020-01802-x}, volume = {133}, number = {3-4}, issn = {0043-5325}, title = {Higher serum uric acid is associated with higher risks of thrombosis and death in patients with primary myelofibrosis}, keyword = {mortality, osteomyelofibrosis, philadelphia chromosome negative myeloproliferative neoplasm, prognosis, thrombotic event} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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